方法：选取我院2013-01/2015-01收治的56例90眼TMD患者作为观察组，选取同期进行眼角膜健康检查的健康人56例88眼作为对照组，分析Terrien角膜边缘退行性变患者的临床特征，使用免疫组织化学术及酶联免疫法(ELISA)对两组研究对象血液中HLA-DR、HLA-DQ以及肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)的表达量进行分析。

结果：TMD患者早期、进展期、膨隆期、穿孔期的眼部透光程度、脂质沉积程度有统计学差异(χ²=10.85、65.32，均P<0.05)； TMD患者早期、进展期、膨隆期、穿孔期的眼部散光有统计学差异(P<0.05)； 观察组患者的炎性因子TNF-α的表达量显著高于对照组，差异有统计学意义(t=19.86，P<0.05)； HLA-DQ、HLA-DR表达差异有统计学意义(t=23.564、45.326，均P<0.05)。

结论：Terrien角膜边缘退行性变是一种以外周血TNF-α升高，伴有HLA-DQ、HLA-DR水平增高，以眼透明度下降，散光及脂质沉着为主要临床特征的炎症性病变，本研究为进一步解释Terrien角膜边缘退行性变发病机制提供试验依据。

METHODS:Fifty-six patients(90 eyes)admitted in our hospital from January 2013 to January 2015 were selected as observation group. At the same period, 56 healthy(88 eyes)for corneal examination were as control group to analyze the clinical features of TMD. With immunohistochemistry and enzyme linked immunoassay method(ELISA), the levels of HLA-DR, HLA-DQ and tumor necrosis factor-α(TNF-α)in blood samples of TMD patients were tested.

RESULTS:The transparent degree of the eye, lipid deposition in TMD patients with early, advanced, swelling and hole-wearing period were significantly different(χ²=10.85, χ²=65.32, P<0.05). Astigmatism in TMD patients with early and advanced, swelling and hole-wearing period were significantly different(P<0.05). The levels of HLA-DR, HLA-DQ and TNF-α in blood samples between the two groups were significantly different(t=45.326, t=23.564, t=19.86, P<0.05).

CONCLUSION: Terrien's marginal degenerative is an inflammatory disease characterized by increased levels of TNF-α, HLA-DQ, and HLA-DR in peripheral blood, decreased corneal transparency, astigmatism and lipid deposition. This research provides experiment evidence for the mechanism of TMD.