方法：将2011-02/2014-02入住我院的88例88眼弱视患儿按照治疗方法分为对照组(44眼)与观察组(44眼)，对照组仅采用短时遮盖疗法，观察组在此基础上给予10g/L阿托品治疗。比较两组患者临床疗效、治疗依从性、视力、弱视眼球矫正球镜度数及不良反应发生情况。

结果：经治疗，观察组临床总有效率为95%(42/44)，显著高于对照组(80%，35/44，P<0.05)； 观察组患儿治疗依从性优良率为95%(42/44)，显著高于对照组(82%，36/44，P<0.05)； 两组患儿初诊视力差异无统计学意义(P>0.05)，但观察组患儿视力提高行数与弱视眼球矫正球镜度数均显著高于对照组(P<0.05)； 观察组不良反应总发生率为9%(4/44)，显著低于对照组(23%，10/44，P<0.05)。

结论：10g/L阿托品联合短时遮盖治疗小儿弱视的临床疗效显著，安全性较高。

METHODS: Eighty-eight children(88 eyes)with amblyopia, staying in hospital from February 2011 to February 2014 for treatment, were divided into control group(n=44)and observation group(n=44). The control group only given short covering therapy was observed. Observation group was given 10g/L atropine treatment besides covering. Clinical efficacy, treatment compliance, visual acuity, corrected spherical degree of amblyopia eye and adverse events were observed and compared.

RESULTS: 1)After treatment, total effective rate of the observation group was 95%(42/44), significantly higher than that of control group(80%, 35/44, P<0.05); 2)excellent compliance rate of the observation group was 95%(42/44), significantly higher than that of control group(82%, 36/44, P<0.05); 3)visual acuity of the two groups when the disease was first diagnosed was not significantly different(P>0.05), but increased number of lines of vision and corrected spherical degree of amblyopia eye in the observation group were significantly higher(P<0.05); 4)in the observation group total rate of adverse events was 9%(4/44), significantly lower than that in the control group(23%, 10/44, P<0.05).

CONCLUSION: The combined therapy, 1% atropine with short covering, is effective and safe for amblyopia in children.