方法：研究纳入116例无糖尿病患者(A组)和101例糖尿病接受超声乳化手术患者(B组)。术前，两组经频域光学相干断层扫描(spectral-domain optical coherence tomography， SD-OCT)和眼底荧光造影(fundus fluorescein angiography， FFA)检测，均未发现黄斑病变或糖尿病黄斑水肿的表现。术后记录超声乳化相关指标。术后每2mo进行FFA检查。出现pCME迹象的患者再次进行SD-OCT评估。

结果：单纯超声乳化术后，两组之间的pCME发生率有显著差异(A组：6.9%，B组：15.8%，P=0.03)。24例患者中，出现19例亚临床pCME。pCME的发生和超声乳化参数(CDE、超声乳化时间和晶状体硬度)显著相关。发生pCME和未发生pCME患者之间糖化血红蛋白(glycosylated hemoglobin， HbA1c)有显著差异(P=0.005)。黄斑囊样水肿和眼轴长度无相关性。

结论：单纯超声乳化术后，无糖尿病和糖尿病患者pCME的发生率有显著差异。大多数患pCME的患者为亚临床表现。CDE和超声乳化时间是pCME的重要影响因素和预测因素。良好的血糖控制可以预防pCME发生。

METHODS: In the study 116 nondiabetic(Group A)and 101 diabetic patients(Group B)underwent phacoemulsification. Preoperatively none of the groups(A+B)had signs of maculopathy or diabetic macular edema documented by spectral-domain optical coherence tomography(SD-OCT)and fundus fluorescein angiography(FFA). Phaco metrics were documented after surgery. FFA was performed two months after each operation. Patients with indications of pCME were reassessed with SD-OCT.

RESULTS: The incidence of pCME after uncomplicated phacoemulsification was statistically significant difference between the two groups(15.8% in Group B versus 6.9% in Group A, P=0.03<0.05). The subclinical pCME appeared in 19 out of 24 patients. There was a significant correlation between parametric values(CDE, phaco-time, hardness of the lens)and pCME occurrence. Glycosylated Hemoglobin(HbA1c)blood levels was statistically significant difference(P=0.005<0.05)between the patients who developed or not pCME. Cystoid macular edema did not correlate with the axial length of the eye.

CONCLUSION: There was statistically significant difference in the incidence of pCME after uneventful phacoemulsification between nondiabetic subjects and diabetics. Most of these patients with pCME had subclinical appearance. CDE and phaco-time data were important factors and predictors to pCME. Good glycemic controls prevent the incidence of pCME.