方法：收集2015-01/07患有进展期圆锥角膜而进行紫外光-核黄素角膜交联手术的患者病例资料。利用双通道系统比较手术前和手术后6mo患者的客观散射指数(OSI)、对比度视力(VA)、调制传递函数截止频率(MTF cut off)和斯特列尔比(SR)。

结果：共收录患者13例16眼。术后6mo裸眼视力、最佳矫治视力、屈光度、Sim-k平均值与术前相比差异无统计学意义(P>0.05)； 眼前节分析仪非侵袭平均泪膜破裂时间(NI Avg-BUT)比术前相比有明显下降，差异有统计学意义(P<0.05)。双通道视觉质量分析系统术后6mo时的MTF cut off、Strehl Ratio、OSI与术前相比差异无统计学意义(P>0.05)； 泪膜分析平均OSI(tear film analysis mean OSI)比术前明显升高，差异有统计学意义(P<0.05)。

结论：角膜交联手术没有使患者的术后视觉质量受到影响，但对术后6mo的泪膜稳定性有轻度影响，长期结果有待进一步观察。

METHODS: Advanced keratoconus patients who underwent UV-riboflavin corneal cross-linking from January to July 2015 were included.The outcomes of their objective scattering index(OSI), predicted visual acuity(VA), the cut-off frequency of modulation transfer function(MTF cut-off), the Strehl ratio(SR)were compared before and 6mo after corneal cross-linking.

RESULTS: A total of 13 patients(16 eyes)were included. There was no statistically significant difference between pre- and 6mo postoperative data in uncorrected visual acuity,best corrected visual acuity,refractions and mean value of Sim-k(P>0.05). Non-invasive average tear film break up time(NIAvg-BUT)detected by the Sirius system decreased after corneal cross-linking(P<0.05). Using double-pass analysis system, no statistically significant change was found in MTF cut off, Strehl Ratio, OSI before and after treatment(P>0.05). Tear Film Analysis Mean OSI increased at 6mo postoperatively(P<0.05).

CONCLUSION: The subjective visual quality isn't effected by corneal cross-linking. The tear stabilities of patients are influenced by these operations at 6mo postoperatively. More observations on long-term effect are needed to be taken in the future.