[关键词]
[摘要]
角膜胶原交联(corneal collagen cross-linking，CXL)技术是通过紫外光A和感光剂核黄素的光化学反应使角膜基质内胶原纤维形成共价键，从而增加胶原纤维机械强度、生物学稳定性及角膜抗扩张能力。角膜融解(corneal melting)是一种与自身免疫相关的非感染性角膜溃疡。我们对角膜融解发病机制、目前主要治疗手段及紫外光A核黄素介导角膜胶原交联术基本原理、在角膜融解方面的实验和临床研究现状等问题进行综述。
[Key word]
[Abstract]
Corneal collagen cross-linking(CXL)could increase the mechanical strength, biological stability and halt ectasia progression due to covalent bond formed by photochemical reaction between ultraviolet-A and emulsion of riboflavin between collagen fibers in corneal stroma. Corneal melting is an autoimmune related noninfectious corneal ulcer. The mechanism of corneal melting, major treatment, the basic fundamental of ultraviolet-A riboflavin induced CXL and the clinical researches status and experiment in CXL were summarized in the study.
[中图分类号]
[基金项目]
