方法：选择2014-01/2015-02在我院眼科门诊就诊的12～18岁轻中度近视的患者85例165眼，按照我院角膜塑形镜验配流程规范验配，采用夜间戴镜8～10h。配镜后随访6mo，观察患者的视力、角膜曲率、屈光度、眼轴长度以及角膜中央厚度、角膜内皮细胞的密度、变异系数和六角形细胞比率的变化。

结果：随访6mo后，与戴镜前相比，患者的裸眼视力、角膜曲率、屈光度与配戴前相比，差异有统计学意义(P<0.05)。眼轴长度、角膜中央厚度、角膜内皮细胞的密度、变异系数和六角形细胞比率有变化，但差异无统计学意义(P>0.05)。患者配戴后主观感觉基本良好，少数患者出现点状角膜上皮脱落，结膜炎等，经治疗后均可恢复，不影响继续配戴。

结论：配戴角膜塑形镜矫治青少年轻中度近视其疗效确切、安全、可靠，但长期配戴须严密观察和随诊。

METHODS:Totally 85 patients(165 eyes, aging from 12 to 18 years old)received orthokeratolog lens treatment in our hospital from January 2014 to February 2015 were followed up for 6mo. All patients wore orthokeratology lens for 8-10h in night after standard optometry for spectacles. The visual acuity, corneal curvature, diopter, the ocular axial length and the central corneal thickness were observed, as well as the corneal endothelial cell density, coefficient of variation and the hexagonal cell ratio.

RESULTS:Followed-up for 6mo, the uncorrected visual acuity, the corneal curvature and the diopter were changed compared before wearing(P<0.05). There was no significant differences on the axial length, the central corneal thickness, the central corneal endothelial cell density, coefficient of variation or the hexagonal cell ratio before and after wearing(P>0.05). Almost all patients felt favorable after 6mo wearing. Only a few patients had a mirror patch corneal epithelium desquamation, conjunctivitis, etc and all could be restored after therapy.

CONCLUSION:Orthokeratology lenses are safe and effective for treating mild and middle myopia in teenagers. But the further study and followed-up are needed for long term wearing.