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[摘要]
目的：研究血小板平均体积(mean platelet volume，MPV)、中性粒细胞/淋巴细胞比值(neutrophil-to-lymphocyte ratio，NLR)与2型糖尿病患者发生视网膜病变(diabetic retinopathy，DR)的关系。
方法：回顾性分析2013-02/2015-07来我院就诊的2型糖尿病患者的病历资料，从中提取MPV和NLR等指标。选取96名健康体检人群作为对照组。采用Logistic回归分析MPV、NLR与2型糖尿病患者发生DR的关系。
结果：共有379例2型糖尿病患者纳入研究，其中328例无DR，51例102眼有DR。2型糖尿病患者的MPV和NLR水平较健康个体明显增高。发生DR的2型糖尿病患者的MPV和NLR较未发生DR的糖尿病患者明显增高。在校正了病程、高血压等因素后，MPV>10fl和NLR>2.6仍然与DR独立相关。
结论：MPV增高和NLR增高与DR的发生独立相关。
[Key word]
[Abstract]
AIM:To investigate the relation of mean platelet volume(MPV), neutrophil-to-lymphocyte ratio(NLR)with diabetic retinopathy(DR)in patient with type 2 diabetes mellitus.
METHODS:Medical records of patients with type 2 diabetes mellitus admitted to our hospital from February 2013 to July 2015 were retrospectively reviewed. Their clinical characteristics, such as MPV and NLR, were extracted. Ninety-six healthy individuals were set as a control. The relation of MPV, NLR with DR were analyzed using logistic regression model.
RESULTS:A total of 379 patients with type 2 diabetes mellitus were included in this study. Among these patients, DR was observed in 51 patients(102 eyes)with DR and 328 patients were without DR. Patients with type 2 diabetes mellitus had significantly higher MPV and NLR, compared with healthy controls. Among patients with type 2 diabetes mellitus, the patients with DR had significantly higher MPV and NLR than the patients without DR. After confounders such as disease duration and hypertension were adjusted, MPV>10fl and NLR>2.6 were independently associated with DR.
CONCLUSION:Increased MPV and NLR are independently associated with DR. Further cohort studies are needed to verify whether MPV and NLR are independent risk factors for DR.
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