方法：回顾性病例研究。利用超声诊断仪、非接触角膜内皮显微镜和角膜地形图仪，测量和观察44例86眼7～17岁青少年近视患者配戴夜戴型角膜塑形镜前和配戴后6mo的角膜中央厚度、角膜内皮细胞密度、中央角膜厚度、角膜曲率和眼轴长度的变化和相关性。

结果：配戴夜戴型角膜塑型镜6mo后，白天裸眼视力稳定在1.0～1.2，无明显眼部并发症。角膜内皮细胞密度稍有减少，但与戴镜前相比差异无统计学意义(P>0.05)。角膜曲率及前房深度无明显变化。角膜中央厚度变薄及眼轴长度仍有增长，差异有统计学意义(P<0.05)。角膜内皮细胞密度与眼轴长度具有相关性(右眼：P=0.005，左眼：P=0.013)，中央角膜厚度与眼轴长度具有相关性(右眼：P=0.019，左眼：P=0.006)。

结论：配戴夜戴型角膜塑型镜6mo，眼轴长度依然有增长，角膜内皮细胞密度降低，中央角膜厚度变薄。

METHODS: Retrospective case-observational study was adopted.Forty-four myopia teenagers(86 eyes)aged 7～17 wearing overnight orthokeratology contact lens were observed and analyzed using ultrasonic diagnostic apparatus, non-contact corneal endothelial microscope and corneal topography. Changes and relative coefficient of corneal endothelium density, central corneal thickness, corneal curvature and eye axial length were examined before and after wearing overnight orthokeratology contact lens for 6mo.

RESULTS:After wearing over night orthokeratology contact lens half a year, visual acuity was stable at 1.0～1.2 without serious complications. No significant differences were found in the density of corneal endothelial cells, corneal curvature and depth of anterior chamber comparing to before wearing. Central cornea thickness was smaller and length of eye axis increased after wearing for 6mo and significant differences were seen(P<0.05). The coefficient of variation was observed between density of corneal endothelial cells and length of eye axis(right eye:P=0.005,left eye:P=0.013), central cornea thickness and length of eye axis(right eye:P=0.019,left eye:P=0.006)after wearing orthokeratology contact lens for 6mo.

CONCLUSION:After wearing overnight orthokeratology for 6mo, eye axis length still increased, corneal endothelial cells density decreased and central cornea thickness thinned.