方法：计算机检索PubMed(1980/2015-09)、CBM(1990/2015-09)、VIP(1989/2015-09)、CNKI(1990/2015-09)和wanfang Data(1990/2015-09)，收集年龄相关性白内障超声乳化联合植入AcrySof三片式人工晶状体与植入Sensar三片式人工晶状体术后后囊膜混浊发生情况的随机对照试验，由两名评价者按照纳入与排除标准筛选研究、提取资料和质量评价后，采用RevMan 5.2软件进行Meta分析。

结果：共纳入5项研究，总计1 036眼(AcrySof组553眼，Sensar组483眼)，随访时限6mo～2a，Meta分析结果显示：(1)AcrySof组术后PCO发生率显著低于Sensar组(OR=0.67，95%CI：0.45～0.99，P=0.04)；(2)两种人工晶状体植入后术眼后囊膜Nd：YAG激光切开术施行率比较，无统计学差异(OR=0.57，95%CI：0.32～1.02，P=0.06)。(3)2a以上长期随访亚组分析中，AcrySof组PCO发生率显著低于Sensar组(OR=0.60，95%CI：0.40～0.91，P=0.02)，两组人工晶状体术后后囊膜激光切开术施行率比较，无统计学差异(OR=0.60，95%CI：0.33～1.09，P=0.09)。

结论：AcrySof三片式人工晶状体相比于Sensar三片式人工晶状体显示出较强的预防后囊膜混浊作用。

METHODS: Such databases as PubMed(1980-Sep 2015),CBM(1990-Sep 2015),VIP(1989-Sep 2015),CNKI(1990-Sep 2015)and WanFang Data(1990-Sep 2015)were searched to collect the randomized controlled trials(RCTs)about AcrySof 3-piece IOL vs Sensar 3-piece IOL for PCO or incidence of Nd:YAG laser capsulotomy.According to the inclusion and exclusion criteria,two reviewers independently screened the literatures,extracted data and assessed the quality of the included studies,then Meta-analysis was conducted using RevMan 5.2 software.

RESULTS: A total of 5 RCTs involving 1 036 eyes(AcrySof group: 553 eyes, Sensar group: 483 eyes)were included, with a follow-up duration of 6mo～2a.The results of Meta-analysis showed that:(1)the incidence of PCO was significantly lower in AcrySof group than that in Sensar group(OR=0.67,95%CI:0.45～0.99,P=0.04);(2)the incidence of Nd:YAG laser capsulotomy after surgeries was similar between AcrySof group and Sensar group(OR=0.57,95%CI:0.32～1.02,P=0.06);(3)in an above 2a long-term follow-up subgroup analysis, AcrySof group indicated a significantly lower incidence of PCO(OR=0.60,95%CI:0.40～0.91,P=0.02), while the Nd:YAG laser capsulotomy incidence was similar between the two groups(OR=0.60,95%CI:0.33～1.09,P=0.09).

CONCLUSION: AcrySof 3-piece IOL seems to have a stronger preventive effect on PCO than Sensar 3-piece IOL. For the quantity limitation of the included studies,this conclusion still needs to be further proved by more high-quality RCTs.