目的：通过检测维吾尔族与汉族糖尿病视网膜病变患者的相关生化指标，判断糖尿病视网膜病变进展与族别有无相关性，进而更准确地指导临床开展地区性治疗，早期检测、早期预防，降低并发症和提高生活质量。

方法：选取年龄38～70岁，眼底荧光造影确诊糖尿病视网膜病变患者120例，其中非增殖期(NPDR)60例，维吾尔族与汉族各30例； 增殖期60(PDR)例，维吾尔族与汉族各30例。所有患者检测空腹静脉血中超敏C反应蛋白(hs-CRP)、血清总胆红素(TBIL)、纤维蛋白原(FIB)、D-二聚体(D-D)指标。

结果：无论是否按族别划分，NPDR组和PDR组在4项指标上均有显著性差异； 其中维汉两族中的hs-CRP比较无显著差异，但TBIL、FIB、D-D在两族中比较差异有统计学意义(P<0.05)，且在维吾尔族人群中更为明显。

结论：新疆维吾尔族糖尿病视网膜病变患者病情普遍较汉族严重，临床上更应引起重视。

AIM:To detect the related biochemical indicators of the Uygur and Han patients with diabetic retinopathy,to judge progression of diabetic retinopathy and evaluate the relation between ethnic and progression. So as to give a more accurate guide for regional clinical treatment, early detection, early prevention, reduce concurrency disease and improve quality of life.

METHODS:One hundred and twenty patients with diabetic retinopathy aged 38～70 were diagnosed by fundus fluorescein angiography, including 60 patients with non-proliferative diabetic retinopathy(NPDR), 30 Uygur and Han respectively(devided into Uygur group 1, Han group 1); 60 patients with proliferative diabetic retinopathy(PDR), 30 Uygur and Han respectively(devided into Uygur group 2, Han group 2). All patients were detected for high-sensitivity C-reactive protein(hs-CRP), serum total bilirubin(TBIL), fibrinogen(FIB), D-dimer(DD)indicators using fasting blood.

RESULTS:Regardless of ethnic, NPDR group and PDR group were significant differences in the four indicators; there was no significant difference between the Han and the Uygur group on the hs-CRP. But for the TBIL, FIB and DD, it was significantly different between the two ethnical groups, and it was more obvious in Uygur group.

CONCLUSION:Diabetic retinopathy generally was more severe in Xinjiang Uygur groups, more attention should be paid in clinical practice.

国家自然科学基金(No.81260150); 新疆医科大学科研创新基金项目(No.XJC2012155)