VEGF、SDF-1、Ki-67、PCNA及Survivin与翼状胬肉的关系分析

Analysis on the relation of pterygium with VEGF,SDF-1,Ki-67,PCNA and Survivin

摘要:

目的：分析血管内皮生长因子(vascular endothelial growth factor，VEGF)、基质细胞衍生因子-1(stromal cell-derived factor 1，SDF-1)、肿瘤增殖抗原(Ki-67)、增殖细胞核抗原(proliferating cell nuclear antigen，PCNA)及生存素(Survivin)与翼状胬肉的关系。

方法：选取2013-01/2015-05于本院进行诊治的79例106眼翼状胬肉患者为观察组，同时期的79例正常结膜者为对照组，然后将两组的组织VEGF、SDF-1、Ki-67、PCNA及Survivin阳性细胞数分级及染色强度分级进行比较，并比较其中不同性别、分期及分型患者的检测结果，同时以Logistic分析上述指标与翼状胬肉的关系。

结果：观察组的组织VEGF、SDF-1、Ki-67、PCNA及Survivin阳性细胞数分级及染色强度分级均高于对照组，不同分期及分型患者的检测结果也存在一定差异(均P<0.05)，而不同性别患者间的检测结果则无明显差异(均P>0.05)，经Logistic分析显示，上述组织指标均与翼状胬肉有密切的关系。

结论：翼状胬肉组织中的VEGF、SDF-1、Ki-67、PCNA及Survivin表达呈现异常状态，上述指标均与翼状胬肉有密切的关系。

Abstract:

AIM:To analyze and study the relation of pterygium with vascular endothelial growth factor(VEGF),stroma cell-derived factor 1(SDF-1),tumor proliferating antigen(Ki-67),proliferating cell nuclear antigen(PCNA)and survivin.

METHODS:Seventy-nine patients(106 eyes)with pterygium from January 2013 to May 2015 in our hospital were selected as observation group. Seventy-nine persons with normal conjunctiva during the same period were selected as control group. Then the number of positive cells and staining intensity classification of the two groups for VEGF,SDF-1,Ki-67,PCNA and survivin were compared,and the detection results of patients with different gender,stages and types were compared too. Then the relation between pterygium and those indexes were analyzed by the Logistic analysis.

RESULTS:The number of positive cells and staining intensity classification of observation group for VEGF,SDF-1,Ki-67,PCNA and survivin were all higher than those of control group,and the detection results of patients with different stages and types had certain differences too(all P<0.05). While the detection results of patients with different gender had no obvious differences(all P>0.05). All those indexes had close relation to pterygium by the Logistic analysis.

CONCLUSION:The expression of VEGF,SDF-1,Ki-67,PCNA and survivin in tissue of patients with pterygium all show abnormal state,and those indexes all have close relation to pterygium.