制备角膜新生血管动物模型的研究进展

Progress on the establishment of corneal neovascularization animal model

摘要:

结膜中的血管过度生长并延伸入角膜形成角膜新生血管(corneal neovascularization， CNV)。血管的异常增生通常来源于角膜受损及自我修复，这是新生血管形成的重要过程。血管的病理性增生阻碍光在眼球内的传播，促进瘢痕形成并引起炎症反应。角膜新生血管会严重影响视力，甚至导致失明。新生血管性眼病是临床上最常见的问题之一。因此进一步的角膜新生血管机制研究是防治新生血管性眼病的关键。角膜新生血管动物模型的选择对研究具有重要意义。本文主要就几种角膜新生血管模型的制备方法作一综述。

Abstract:

Corneal neovascularization(CNV)is the extensive growth of blood vessels from conjunctiva into cornea. Abnormal angiogenesis plays an important role in the process of CNV, which may result from corneal wound and self-healing. The pathologic growth of blood vessels blocks light, promotes scar formation and causes inflammation, which impairs visual acuity. It is a sight-threatening condition that can decreases eyesight and even leads to blindness. Neovascular eye disease is one of the most common eye diseases in clinical admissions. So, further mechanistic studies are the key to the prevention and treatment of CNV. Determination on the CNV animal models is essential in eye diseases researches. Several main methods of CNV models establishment are summarized in this review.