方法：我们分别测量50只50眼昆明种小鼠在出生后第14、21、28、35和56d视网膜电图，分析比较各时间点Rod-ERG b波、Max-ERG a及b波、Cone-ERG的a及b波、OPs O1及O2波幅值及峰潜时、Flick-ERG幅值。

结果：Max-ERG a波峰潜时(各时间点95%可信区间依次为15.00～18.60、12.00～15.00、13.20～14.40、13.20～15.00、13.20～15.00ms)、OPs O1波峰潜时(各时间点95%可信区间依次为15.00～19.80、13.80～18.00、13.20～14.40、13.80～15.60、13.80～15.60ms)和Flick-ERG幅值(各时间点95%可信区间依次为0.97～3.28、0.85～2.32、0.91～3.49、0.94～2.68、0.98～3.69μV)在各周龄间无统计学差异(P>0.05)； Cone-ERG a波峰潜时(各时间点95%可信区间依次为25.20～55.20、27.00～40.20、27.00～38.40、25.20～43.80、23.40～37.80ms)在出生后14d和28d间存在统计学差异(P<0.05)、出生后14d与出生后21d、28d间Cone-ERG b波峰潜时(各时间点95%可信区间依次为70.80～88.20、56.40～78.60、60.00～75.60、60.60～87.00、62.40～81.60ms)均有统计学差异； 同时出生后第14d与其他时间点间Rod-ERG b波峰潜时(各时间点95%可信区间依次为87.00～114.00、53.40～73.80、52.2～63.6、55.20～71.40、57.60～67.80ms)及幅值(各时间点95%可信区间依次为64.21～195.07、133.79～355.71、130.62～355.96、190.92～448.97、239.26～462.40μV)、Max-ERG b波峰潜时(各时间点95%可信区间依次为67.20～107.40、32.40～54.60、31.20～36.60、31.80～42.00、34.20～41.40ms)及幅值(各时间点95%可信区间依次为160.64～344.48、281.74～590.09、284.91～716.80、358.64～737.55、406.98～810.55μV)、OPs O2波峰潜时(各时间点95%可信区间依次为49.8～69.6、29.40～42.60、28.80～33.60、28.80～37.80、31.20～37.20ms)和波幅值(各时间点95%可信区间依次为5.43～24.84、54.38～147.52、65.55～201.60、46.33～164.79、49.07～148.32μV)以及OPs O1(各时间点95%可信区间依次为11.60～21.36、6.77～53.71、32.96～76.42、34.06～70.37、35.58～63.35μV)和Cone-ERG b波幅值(各时间点95%可信区间依次为5.10～15.85、9.61～24.88、14.96～40.73、14.87～28.54、13.83～51.98μV)均存在统计学差异。OPs O1波在P14时即已存在，而有一只小鼠(1/10)OPs第二波群在第2wk时波形不明显。

结论：本实验结果在一定程度上证实了小鼠ERG中各波形的起源。由于小鼠ERG在发育过程中的变化，在测量小鼠ERG时应当考虑到小鼠发育阶段对结果的影响。

METHODS: The ERG of 50 mice(50 eyes)of KUNMING at the ages of postnatal 14d(P14), P21, P28, P35 and P56 were measured respectively. The implicit times and amplitudes of b wave of Rod-ERG, a and b waves of Max-ERG, a and b waves of Cone-ERG and O1 and O2 waves of OPs at different ages, as well as amplitude of Flick-ERG, were compared.

RESULTS: The Max-ERG a-waves(the 95%CI were 15.00～18.60, 12.00～15.00, 13.20～14.40, 13.20～15.00, 13.20～15.00, respectively), OPs O1(the 95%CI were 15.00～19.80, 13.80～18.00, 13.20～14.40, 13.80～15.60, 13.80～15.60, respectively)waves shared the implicit times at the different stages, and the Flick-ERG(the 95%CI were 0.97～3.28, 0.85～2.32, 0.91～3.49, 0.94～2.68, 0.98～3.69μV, respectively)shared the amplitudes also. There was no significant difference among the weeks(P>0.05). The implicit times of the Cone-ERG a-waves(the 95%CI were 25.20～55.20, 27.00～40.20, 27.00～38.40, 25.20～43.80, 23.40～37.80, respectively)between P14 and P28 were distinct with statistical difference(P<0.05). The implicit times of Cone-ERG b-waves(the 95%CI were 70.80～88.20, 56.40～78.60, 60.00～75.60, 60.60～87.00, 62.40～81.60ms, respectively)at P14 were statistically different from those at P21 and at P28. The implicit times and amplitudes of Rod-ERG b-waves(the 95%CI were 87.00～114.00, 53.40～73.80, 52.2～63.6, 55.20～71.40, 57.60～67.80ms, and 64.21～195.07, 133.79～355.71, 130.62～355.96, 190.92～448.97, 239.26～462.40μV, respectively), Max-ERG b-waves(the 95%CI were 67.20～107.40, 32.40～54.60, 31.20～36.60, 31.80～42.00, 34.20～41.40ms, and 160.64～344.48, 281.74～590.09, 284.91～716.80, 358.64～737.55, 406.98～810.55μV, respectively), and OPs O2 waves(the 95%CI were 49.8～69.6, 29.40～42.60, 28.80～33.60, 28.80～37.80, 31.20～37.20ms, and 5.43～24.84, 54.38～147.52, 65.55～201.60, 46.33～164.79, 49.07～148.32μV, respectively)at P14 were different from those at other stages, and the amplitudes of OPs O1(the 95%CI were 11.60～21.36, 6.77～53.71, 32.96～76.42, 34.06～70.37, 35.58～63.35μV, respectively)and Cone-ERG b-waves(the 95%CI were 5.10～15.85, 9.61～24.88, 14.96～40.73, 14.87～28.54, 13.83～51.98μV, respectively)were from those at other stages also, and there were significant differences. The O1 wave of OPs had been present at P14, but the second cluster of OPs of one mouse(1/10)had not been obvious at the same time.

CONCLUSION: The experiment confirms that the different waves come from different cells in retina in mice at certain degree. Due to the change of the ERG in the development of mice, so it should be considered that the different development stages will affect the results when measuring the ERG of mice.