方法：采用临床病例系列研究，将122例单眼发病NAION患者分为3组，所有患者均接受常规治疗。对照组A(40例40眼)给予复方樟柳碱注射液2mL/次颞浅动脉旁皮下注射，2次/d； 对照组B(41例41眼)鼠神经生长因子30μg/次肌肉注射，1次/d； 联合组(41例41眼)同时给予复方樟柳碱和鼠神经生长因子治疗，连续治疗4wk。每天观察视力、眼底，治疗结束后检查记录最佳矫正视力(BCVA)、视野、OCT，对结果进行统计分析。

结果：联合组视力、视野恢复优于两对照组，差异有统计学意义(P<0.05)，视神经纤维层变薄联合组少于两对照组，差异有统计学意义(P<0.05)； 两对照组视力、视野、视神经纤维层变化均无统计学差异(P>0.05)。对照组A治疗有效率为70%，对照组B有效率为65.9%，联合组有效率为92.7%，联合组有效率显著高于两对照组，差异有统计学意义(P<0.05)； 两对照组间总体治疗效果无统计学差异(P>0.05)。

结论：鼠神经生长因子联合复发樟柳碱可显著提高NAION治疗效果。

METHODS: Clinical case series study was applied. One hundred and twenty-two patients with monocular onset NAION were randomly divided into three groups. Routine treatment was given to all of patients. Control group A(40 patients with 40 eyes)were undergone subcutaneous injection of compound anisodine besides superficial temporal artery, 2mL each time, twice per day; control group B(41 patients with 41 eyes)were given intramuscular injection of mouse nerve growth factor, 30μg each time, once per day; and the combined group(41 patients with 41 eyes)received compound anisodine and mouse nerve growth factor for four consecutive weeks. Visual acuity and fundus were observed every day during the treatment period. When the treatment finished, the best corrected visual acuity(BCVA), visual field and OCT were checked and recorded. The results were analyzed.

RESULTS: The recovery of visual acuity and visual field in the combined group was better than those of two control groups(P<0.05). Optic nerve fiber layer became thinner in the combined group which was still thicker than that in the control groups after the treatment, and there was significantly statistical difference(P<0.05). Visual acuity, visual field and retinal nerve fiber layer had no statistical differences between control group A and control group B(P>0.05). The effective rates of the three groups were respectively 70%(control group A), 65.9%(control group B), 92.7%(the combined group). The overall effective rate of patients in the combined group was significantly higher than that of two control groups(P<0.05), while the clinical efficacy of two control groups had no statistical difference(P>0.05).

CONCLUSION: Mouse nerve growth factor combined with compound anisodine has a remarkable effect on the treatment of NAION.