葡萄膜炎性黄斑水肿对视功能的影响

Impact assessment of uveitis macular edema on visual function

摘要:

目的：探讨葡萄膜炎性黄斑水肿对视力、视野损害的相关性。

方法：此研究为单中心、回顾性的、对临床中发现的中间、后部或全葡萄膜炎治疗的特征性对照研究。葡萄膜炎性黄斑水肿患者132例248眼，接受视力、频域光学相干断层扫描、微视野检测。

结果：葡萄膜炎性黄斑水肿与视力、视野的损害具有明显的相关性(P<0.05)。不同类型的黄斑水肿对应不同的视力损害：不伴有黄斑中心凹厚度增加的囊腔型可产生中等程度的视力损害，平均10个字母； 不伴有囊腔而仅有黄斑中心凹厚度增加型可产生更大程度的视力损害，平均19个字母； 而同时伴有囊腔、黄斑中心凹厚度增加的黄斑囊样水肿型可产生最大程度的视力损害，平均26个字母。入选的所有黄斑水肿都产生了不同程度的视野损害：与黄斑中心凹的的厚度密切相关，即厚度越大，视野损害的范围越广，差异具有统计学意义(P<0.05)，而与是否具有囊腔关系不大。

结论：黄斑水肿对应的视功能损害提示我们在以后的葡萄膜炎治疗过程中，对黄斑水肿的治疗也应作为一个重要方面去关注； 对葡萄膜炎性黄斑水肿的视功能损害评估，应该从视力和微视野两方面关注。

Abstract:

AIM: To investigate the impact of uveitis macular edema on vision and vision field impairment.

METHODS: This study was a single center, retrospective controlled study of clinical characteristic found in the middle, rear or panuveitis treatment. Totally 132 patients(248 eyes)with uveitis macular edema were selected and accepted the vision, the frequency-domain optical coherence tomography, micro-perimetry examination.

RESULTS: Uveitis macular edema had significant correlation with visual acuity and visual field damage(P<0.05). Different types of macular edema corresponded to different visual impairment: not associated with foveal thickness increased cavity type could produce moderate visual impairment, with an average 10 letters; not associated with cysts and only foveal thickness increases type could produce a greater degree of visual impairment, with an average 19 letters; and accompanied by cysts, foveal thickness increased cystoid macular edema type could produce the greatest degree of visual impairment, with an average 26 letters. All selected macular edema had varying degrees of vision impairment: closely related to the thickness of the fovea, that the greater the thickness, the wider the range of vision impairment, the difference was statistically significant(P<0.05), regardless of whether cysts had little relationship.

CONCLUSION: The damage of macular edema corresponding visual function prompts us later in the course of uveitis treatment, the treatment of macular edema should also serve as an important aspect to focus on. Assessment of macular edema, uveitis visual impairment should be to focus on the vision and the vision of both micro and so on.