眼眶成纤维细胞与甲状腺相关眼病研究进展

Research advances of orbital fibroblasts and thyroid associated ophthalmopathy

摘要:

甲状腺相关眼病的发病机制尚不完全清楚，临床缺乏确实有效的治疗方法。眼眶成纤维细胞作为靶细胞和效应细胞参与了自身免疫、炎症反应和组织重塑等多个病理过程。我们就眼眶成纤维细胞在甲状腺相关眼病发病机制中的作用的研究进展做一综述，并讨论该领域治疗研究方向。

Abstract:

The pathogenesis of Thyroid associated ophthalmopathy is not fully clear. Thyroid associated ophthalmopathy is lack of sustained and effective drug treatment at present. As target cells and effect cells, orbital fibroblasts are involved in the pathological processes of remodeling, inflammation and immune response in orbit tissue. The present review focuses on the study of orbital fibroblasts in the pathogenesis of thyroid related ophthalmopathy, discusses the future orientation in this field of treatment.