方法：前瞻、随机、对照研究。将2014-01/10在我院进行超声乳化白内障吸除联合人工晶状体植入术的老年性白内障患者随机分为两组，分别在术后使用氯替泼诺妥布霉素滴眼液(氯替泼诺组)和妥布霉素地塞米松滴眼液(地塞米松组)。观察术前术后的眼压以及炎症评分、舒适度评分。

结果：共有143例143眼入选，其中氯替泼诺组有81例，地塞米松组有62例。两组在术后不同时间点的炎症评分和舒适度评分均无统计学差异。术后第14d地塞米松组的平均眼压为16.5±3.1mmHg，显著高于氯替泼诺组14.7±3.7mmHg(P=0.004)。在术后第14d，地塞米松组有2例眼压高于21mmHg，停药后眼压可恢复至正常。

结论：氯替泼诺妥布霉素滴眼液和妥布霉素地塞米松滴眼液在白内障超声乳化吸除术后的抗炎效果相近，但是氯替泼诺妥布霉素滴眼液对眼压的影响更小，更安全。

METHODS: In this prospective, comparative, randomized controlled trial, patients with senile cataract who underwent phacoemulsification combined intraocular lens implantation in our hospital from January 2014 to October 2014 were enrolled, which were randomly divided into two groups. Patients were given lotrprednol-tobramycin(LE/T group)and dexamethasone-tobramysin(D/T group)eyedrops respectively. Preoperative and postoperative intraocular pressure, malnutrition inflammation score, bruggrmann comfort scale were observed.

RESULTS:A total of 143 eyes of 143 cases were enrolled, of them 81 cases were in the LE/T group and 62 in the D/T group. There were no statistically significant differences between the two groups in malnutrition inflammation score and bruggrmann comfort scale. The average intraocular pressure was 16.5±3.1mmHg in D/T group after 14d postoperation, which was obviously higher than LE/T group(14.7±3.7mmHg, P=0.004). After 14d postoperation, the intraocular pressure of 2 cases were >21mmHg, which were back to normal after drug withdrawal.

CONCLUSION: The anti-inflammatory effects lotrprednol-tobramycin and tobramysin-dexamethasone eyedrops are similar after phacoemulsification. However, lotrprednol-tobramycin has little influence in intraocular pressure, and more safety.