普拉洛芬治疗结膜松弛症所致眼表泪液异常的疗效

Rapeutic effects analysis of Pranoprofen on tear dynamic abnormity induced by conjunctivochalasis

摘要:

目的：观察普拉洛芬治疗结膜松弛症(conjunctivochalasis，CCh)所致眼表泪液异常的临床效果。

方法：挑选因CCh所致的以溢泪症状为主的患者共70例70眼，参照张氏分级标准分为Ⅱ，Ⅲ，Ⅳ级3组。所有患者采用普拉洛芬点眼2wk，根据症状、染料消失试验、苦味试验和泪膜破裂时间做各组治疗前后的疗效分析。

结果：普拉洛芬治疗后2wk，Ⅰ、Ⅱ级患者症状改善最明显，Ⅲ级次之，Ⅳ级最差； 染料消失试验Ⅱ级阳转率最高，Ⅲ级次之，Ⅳ级最少，三组之间有统计学差异(P<0.05)； Ⅱ级苦味试验时间较前缩短(P<0.05)，泪膜破裂时间较前延长(P<0.05)，而Ⅲ、Ⅳ级时间较前无改变(P>0.05)。

结论：普拉洛芬对结膜松弛症Ⅱ级所致的眼表泪液异常治疗有效。

Abstract:

AIM: To investigate the therapeutic effects of Pranoprofen on tear dynamic abnormity induced by conjunctivochalasis(CCh).

METHODS: Seventy cases(70 eyes)whose the main symptoms was epiphora induced by CCh were divided into Ⅱ, Ⅲ and Ⅳ in 3 groups according to Zhang's grading standards, meanwhile, all the patients were treated with the eye drops of Pranoprofen for 2wk. After that, the curative effect of each group was analyzed before and after treatments according to the symptoms, dye disappearance test, bitter taste test and tear break-up time.

RESULTS: After 2wk treatment of Pranoprofen, the symptom of patients at grade Ⅰ and Ⅱ improved obviously grade Ⅲ improved more, grade Ⅳ did little. The positive rate of dye disappearance was the highest in grade Ⅱ, the second in grade Ⅲ, and the third in grade Ⅳ. There was significant difference among the 3 groups(P<0.05). The time of bitter taste test was shortened(P<0.05)and the tear break-up time was prolonged(P<0.05)in grade Ⅱ after treatment, however, the time of those in grade Ⅲ and Ⅳ had not changed than before(P>0.05).

CONCLUSION: Pranoprofen has good effects on tear dynamic abnormity induced by grade Ⅱ of cch.