SIRT1与眼科疾病的研究进展

Research progress of SIRT1 with eye diseases

摘要:

沉默信息调节因子相关酶1(sirtuin type1，SIRT1)是一种细胞代谢辅酶NAD⁺依赖的Ⅲ类组蛋白去乙酰化酶，通过转录调控，参与基因转录、能量代谢以及细胞衰老过程的调节，具有延长生物寿命和延缓多种年龄相关性疾病发展的作用，在抗衰老研究领域备受关注。近年的研究显示SIRT1在眼科多种疾病的发病机制中占有重要的地位，尤其是眼表疾病、青光眼、白内障、葡萄膜炎以及眼底病等，针对SIRT1活性的促进可能成为眼科新型药物的治疗靶点。本文将对SIRT1与眼科疾病的研究报道进行综述。

Abstract:

Silent information regulator protein 1(SIRT1)is a kind of histone deacetylases class III on which cell metabolism coenzyme NAD⁺ is dependent. By the transcriptional regulation, it participates in the regulation of gene transcription, energy metabolism and cell aging process, which can prolong the lifespan of organisms and delay the development of various age-related diseases and has attracted much attention in the field of anti-aging research. In recent years, studies have shown that SIRT1 occupies an important position in the pathogenesis of many ophthalmic diseases, especially in ocular surface diseases, glaucoma, cataracts, uveitis, and ocular fundus diseases, etc. There is a possibility that the promotion of SIRT1 activity would be the new drug target of ophthalmic therapy. The paper will review studies on SIRT1 and ophthalmic diseases.