盐酸环喷托酯滴眼液在儿童屈光状态检查中的应用

Clinical effect of cyclopentolate hydrochloride on cycloplegia in children

摘要:

目的：探讨10g/L盐酸环喷托酯滴眼液在小儿屈光状态检查中的应用。比较其与阿托品在散瞳验光中麻痹睫状肌的效果，用以指导临床工作。

方法：采用自身配对设计方法，对年龄3～12岁118例236眼(其中近视40例80眼，远视78例156眼，合并有散光73例146眼)先采用10g/L盐酸环喷托酯滴眼液滴眼3次散瞳(每次间隔5min)，末次点眼1h后进行检影验光。间隔3d后重新点10g/L阿托品眼膏1wk(每晚1次)重新进行散瞳检影验光。按屈光度分成近视组、远视组、散光组，其中散光度数是将柱镜度数独立分离出来统计。将两种散瞳药的验光结果进行比较。

结果：近视组使用两种方法散瞳验光后屈光度值分别为-2.25±1.31D，-2.23±1.32D，差异无统计学意义(P=0.109)； 远视组应用两种药物散瞳验光后屈光度分别为3.76±2.4D， 4.39±2.6D，差异有统计学意义(P=0.000)； 散光组应用两种药物散瞳验光后屈光度值分别为1.35±1.19D，1.38±2.00D，差异无统计学意义(P=0.374)。

结论：盐酸环喷托酯滴眼液可用于临床上3～12岁近视、散光儿童的散瞳验光。但在远视儿童初次就诊仍需点阿托品眼膏散瞳验光。

Abstract:

AIM: To explore the application of 10g/L cyclopentolate chloride eye drops in children, and to compare the different effectiveness of cycloplegia between 10g/L cyclopentolate chloride and atropine in Chinese children.

METHODS: A total of 236 eyes of 118 children aged 3～12 years old were enrolled in this study including 80 eyes of 40 children with myopia, 156 eyes of 78 children with hyperopia and 146 eyes of 73 children combined with astigmatism. 10g/L cyclopentolate chloride eye drops were used once per 5min for 3 times and refractive diopter was obtained 1h after the last drop of cyclopentolate. Three days after that, 10g/L atropine was then used 1 time per night for 1wk and optometry was performed again. The children were divided into 3 groups(myopia, hyperopia and astigmatism group)according to the refractive status, in which astigmatism was independent of the degree of separation of cylinder statistics. The results of retinoscope refraction were then compared between 10g/L cyclopentolate and 10g/L atropine.

RESULTS: The refractive diopter was -2.25±1.31D after 10g/L cyclopentolate eye drops and -2.23±1.32D after 10g/L atropine in myopic group. The refractive diopter was 1.35±1.19D and 1.38±2.00D in astigmastic group. No significant difference was found in myopic group and astigmastic group(P=0.109, P=0.374). While in the hyperopic group, the refractive diopter was 3.76±2.4D after 10g/L cyclopentolate eye drops, which was lower than that after 10g/L atropine 4.39±2.6D(P=0.000).

CONCLUSION: The results of this study suggest that 10g/L cyclopentolate chloride eye drops can be used in myopia and astigmatism children, and 10g/L atropine should be used in hyperopia children.