方法：回顾性分析了2011-10/2014-07于我院眼科接受诊疗的BK患者60例60眼的临床资料，采用PTK术对其进行治疗。比较手术前后最佳矫正视力(BCVA)、角膜曲率、角膜散光度数、角膜厚度及角膜内皮细胞密度(ECD)、术后并发症发生情况。

结果：本组患者术前BCVA、角膜曲率、角膜散光度数分别为0.05±0.01，37.02±5.38，1.08±0.67D，均显著小于术后(分别为0.45±0.13，46.27±7.02，1.92±0.73D)，差异均具有统计学意义(P<0.05)； 术前角膜厚度为492.33±18.27μm，显著大于术后377.27±22.49μm(P<0.05)； 本组手术前后视力差异具有统计学意义(P<0.05)； 术后随访6mo，未见原有角膜病变复发，仅2例术后出现轻微角膜上皮下雾状混浊，给予激素类滴眼液点眼后均完全消退。

结论：准分子激光术在治疗大泡性角膜病变中的临床疗效非常显著，安全性高，应在临床上进行推广。

METHODS: A retrospective analysis of 60 cases(60 eyes)of BK patients from Department of Ophthalmology in our hospital October 2011 to July 2014 was undergone. Clinical data of all patients with treatment of PTK were analyzed. Best corrected visual acuity(BCVA), corneal curvature, corneal astigmatism, corneal thickness and corneal endothelial cell density(ECD), postoperative complications before and after surgery were compared.

RESULTS: BCVA, corneal curvature, corneal astigmatism of patients before surgery were 0.05±0.01 and 37.02±5.38, 1.08±0.67D, which were significantly less than those of postoperative(respectively 0.45±0.13 and 46.27±7.02, 1.92±0.73D), the differences were statistically significant(all P<0.05). Corneal thickness of patients was 492.33±18.27μm before surgery, which was higher than that after surgery 377.27±22.49μm(P<0.05). The difference of visual acuity before and after surgery was statistically significant in this group(P<0.05). During the follow-up period of 6mo, no recurrence of the original corneal lesions, only 2 cases of postoperative slight haze, it was completely dissipated after given the hormone eye drops.

CONCLUSION: Excimer laser technology has high safety in the treatment of bullous keratopathy, it should be promoted in clinical practice.