[关键词]
[摘要]
目的：应用Meta分析探讨IGF-1基因2个多态性位点(rs6214 和rs12423791)与高度近视易患性的关系。
方法：两名作者独立检索PubMed、EMBASE、中国期刊全文数据库(CNKI)从建库到2014-03-12发表的文献，合并效应采用比值比和95%可信区间进行评价，Meta分析软件运用RevMan5.2和Stata 12.0。
结果：五篇病例对照研究进入Meta分析，包括病例组2585例，对照组3327例，各基因模型均显示两个位点基因多态性与高度近视易患性无显著相关性。
结论：现有证据表明，尚不能认为IGF-1两个位点rs6214A/G，rs12324791G/C基因多态性与高度近视有关联性。
[Key word]
[Abstract]
AIM: To investigate the association between the single nucleotide polymorphisms(SNP)(rs6214 and rs12423791)in IGF-1 and high myopia susceptibility by performing a Meta-analysis.
METHODS: PubMed, EMBASE, and Chinese National Knowledge Infrastructure(up to March 12, 2014)were searched by two authors independently. Crude odds ratios with 95%CIs were used to assess the strength of the associations between SNP rs6214, rs12324791 and high myopia. Statistical analysis was performed using the program RevMan5.2 software(Revman; The Cochrane Collaboration, Oxford, UK)and STATA 12.0 software(Stata Corporation, College Station, TX, USA).
RESULTS: Five case-control studies with involving 2585 patients with high myopia and 3327 controls were included in this Meta-analysis. No statistical evidence of significant association was found in all genetic models of rs6214A/G and rs12324791G/C.
CONCLUSION: This Meta-analysis suggested that the rs6214A/G and rs12324791G/C mutation in the insulin-like growth factor-1 are not significantly associated with high myopia.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.81360146)
