方法：采用光学相干断层扫描(optical coherence tomography，OCT)对我院门诊诊断为早期PD的15例15眼患者和18例18眼正常对照者进行以视盘中心为圆心、直径为3.46mm的环形扫描。扫描分为颞侧、上方、鼻侧、下方、颞下、颞上、鼻下、鼻上8个象限进行。对比分析两组受检者8个象限的视网膜神经纤维层(retinal nerve fiber layer，RNFL)厚度及平均RNFL厚度。

结果：正常对照组颞侧、上方、鼻侧、下方、颞下、颞上、鼻下、鼻上RNFL厚度和平均RNFL厚度分别为83.2±17.5， 132.7±17.4，83.7±22.3，141.5±15.3，117.9±24.5，120.8±21.2，110.2±27.7，109.6±20.6，109.9±8.5μm，早期PD患者颞侧、上方、鼻侧、下方、颞下、颞上、鼻下、鼻上RNFL厚度和平均RNFL厚度分别为68.7±13.5，128.1±25.3，76.5±17.8，128.6±13.2，103.3±14.1，102.6±23.7，96.6±15.0，101.2±20.9，102.3±11.9μm。两组比较，下方、颞侧、颞下、颞上RNFL厚度和平均RNFL厚度差异有统计学意义(t=2.595，2.700，2.153，2.330，2.131； P=0.014，0.011，0.040，0.026，0.041)。

结论：早期PD患者下方、颞侧、颞下、颞上及平均RNFL厚度较正常者明显变薄。

METHODS: Fifteen eyes of 15 PD patients in early stage and 18 eyes of 18 controls were chosen to take RNFL examination by optical coherence tomography(OCT). Circular scans were taken around the optic nerve head(diameter=3.46mm)to record the features of RNFL. Scanning areas included eight quadrants of the temporal, superior, nasal, inferior, inferior-temporal, superior-temporal, inferior-nasal and superior-nasal quadrant. RNFL thickness was comparatively analyzed in eight quadrants and the average level in two groups.

RESULTS: RNFL thickness in two groups in temporal, superior, nasal, inferior, temporal- inferior, temporal- superior, nasal-inferior, nasal-superior were:(control/PD)83.2±17.5μm/68.7±13.5μm, 132.7±17.4μm/128.1±25.3μm, 83.7±22.3μm/76.5±17.8μm, 141.5±15.3μm/128.6±13.2μm, 117.9±24.5μm/103.3±14.1μm, 120.8±21.2μm /102.6±23.7μm, 110.2±27.7μm/96.6±15.0μm, 109.6±20.6μm/101.2±20.9μm. The average RNFL thickness in controls was 109.9±8.5μm while it showed 102.3±11.9μm in PD group. RNFL thickness in inferior, temporal, inferior-temporal, superior-temporal and the average RNFL thickness were statistically different in two groups(t=2.595,2.700,2.153,2.330,2.131; P=0.014,0.011,0.040,0.026,0.041).

CONCLUSION: RNFL thickness in inferior, temporal, inferior temporal, superior temporal and the average RNFL thickness are significantly thinner in mild PD than those in the controls.