方法：临床收集无明显视力下降的糖尿病患者共87眼，根据糖尿病视网膜病变的国际分期，分别获得DR0期54眼和DR1期33眼。进行黄斑区光学相干断层扫描，扫描模式为512×128，记录黄斑部平均视网膜厚度及黄斑容积，并与正常人的黄斑平均视网膜厚度及黄斑容积比较。

结果：在DR1期的患者中黄斑平均视网膜厚度及黄斑容积均高于DR0期组和正常对照组，且具有统计学意义，DR0期组和健康对照组此两项指标差异不具有统计学意义。

结论：随着糖尿病视网膜病变加重，黄斑部视网膜厚度有增厚趋势，尽管视力无明显损害，但已经有轻度形态学改变，利用OCT可更早发现糖尿病患者的黄斑区变化，为诊断和早期干预提供一定临床依据。

METHODS: A total of 87 eyes were collected in diabetic group. According to the international stage of diabetic retinopathy, these cases were divided into two subgroups: DR0 stage 54 eyes and DR1 stage 33 eyes. All the cases were received optical coherence tomography(OCT)scan in macular area; the scanning model is 512×128; recording macular average thickness and macular volume, and compared with healthy subjects.

RESULTS: Macular average thickness and macular volume were higher in DR1 group than those in DR0 stage and control group, and differences were having statistical significance. But DR0 group and control group differences of the two indexes were not statistically significant.

CONCLUSION: With the aggravation of diabetic retinopathy, the macular thickness tends to be thicken. Although without obvious visual loss, there have been slight morphological changes. Using OCT scan can find fundus changes earlier in patients with diabetes mellitus, and provide clinical basis for both early diagnosis and treatment.