[关键词]
[摘要]
增殖性糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)是一种以眼内新生血管形成为特征的糖尿病并发症。眼内新生血管的形成是当今世界主要致盲原因之一。血管内皮生长因子(vascular endothelial growth factor，VEGF)与色素上皮衍生因子(pigment epithelium-derived factor，PEDF)作为眼内新生血管形成最主要的细胞因子，近年来成为研究热点。本文就VEGF和PEDF在PDR中的研究进展进行综述。
[Key word]
[Abstract]
Proliferative diabetic retinopathy(PDR)is a group of disease characterized by neovascular disease complication of diabetes mellitus. Neovascular diseases of eye are one of the major causes of blindness of the world. Recent studies showed that vascular endothelial growth factor(VEGF)and pigment epithelium-derived factor(PEDF)are now accepted as the key cytokine in the development of diabetic retinopathy. Recent progress in the investigation of VEGF and PEDF of PDR are summarized in this review.
[中图分类号]
[基金项目]
福建省科技厅重点项目(No.2012Y0055)
