[关键词]
[摘要]
视网膜母细胞瘤(retinoblastoma，RB)是婴幼儿最常见的眼内恶性肿瘤，预后较差。MicroRNAs是 一类存在于真核细胞中的非编码单链小分子RNA，通过对mRNA的降解和翻译抑制调控基因表达。MicroRNAs作为癌基因或抑癌基因，可直接参与RB的发生、发展，并在RB的早期诊断和临床靶向治疗中具有重要作用。本文主要对近年来RB中microRNAs的表达情况以及其在RB形成中的作用机制的研究进行简要综述。
[Key word]
[Abstract]
Retinoblastoma(RB)is the most common intraocular malignancy of children with extremely poor prognosis. MicroRNAs are small non-coding single-stranded RNAs in eukaryotic cells, which regulate the expression of gene by mRNA degradation or translation inhibition. MicroRNAs, acting as oncogenes or tumor suppressor genes, are associated with the occurrence and development of RB directly, which is vital for the early diagnosis and clinical targeted therapy of RB. This review summarized the expression of microRNAs in RB and the related mechanism.
[中图分类号]
[基金项目]
广西壮族自治区卫生厅科研课题(No.Z2008159)
