[关键词]
[摘要]
目的：通过频域光学相干断层扫描(spectral-domain optical coherence tomography， SD-OCT)观测特发性黄斑裂孔患者对侧眼中心凹的形态结构变化。
方法：将50例50眼研究对象分为两组：组1为25例特发性黄斑裂孔患者，组2为25位健康人(对照组)。使用RTVue 100(Optovue， Inc.， Fremont， CA， USA)的“交叉十字”SD-OCT扫描模式，对所有研究对象进行黄斑中心凹广域B型方向扫描。通过卡尺工具测量二维横断面图上中心凹的形态面积。
结果：组1中心凹形态面积为0.159±0.03mm2，组2为0.079±0.01mm2。两组比较，差异有统计学意义(P<0.001)。 组1中有1例患者对侧眼产生黄斑裂孔。
结论：同健康人相比，特发性黄斑裂孔患者的对侧眼中心凹形态有增大趋势。该发现结合其他的一些玻璃体黄斑的致病因素，可能导致特发性黄斑裂孔。
[Key word]
[Abstract]
AIM: To evaluate anatomic foveal configuration changes in fellow eyes of patients with idiopathic macular hole using spectral-domain optical coherence tomography(SD-OCT).
METHODS: Fifty eyes of fifty patients were studied and divided in two groups: group 1=25 patients with idiopathic macular hole and group 2=25 healthy individuals(control group). SD-OCT cross line scans were obtained using RTVue 100(Optovue, Inc., Fremont, CA, USA). The widest foveal B-scan was selected on each patient. Bi-dimensional foveal configuration was measured in mm2 using caliper tool.
RESULTS:The mean foveal configuration in group 1 was 0.159±0.03mm2 and in group 2 was 0.079±0.01mm2. The difference between the two groups was statistically significantly(P<0.001). In group 1, one patient developed a macular hole in the fellow eye.
CONCLUSION: Fellow eyes of patients with idiopathic macular hole tend to have an enlarged foveal configuration when compared to healthy subjects. Our finding combined with other vitreomacular risk factors may play a role in idiopathic macular hole formation.
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