方法：对来我院行LASIK手术的患者64例64眼分析术后6mo后表面变化与制瓣方式、角膜瓣厚度(flap thickness，FT)、切削厚度(ablation thickness，AT)、术后剩余基质厚度(postoperative residual corneal stroma thickness，RCST)、术前角膜最薄点厚度(preoperative thinnest corneal thickness，CT)、角膜瓣厚度/术前角膜最薄点厚度(flap thickness/ preoperative thinnest corneal thickness，FT/CT)、切削厚度/术前角膜最薄点厚度(ablation thickness/ preoperative thinnest corneal thickness，AT/CT)、剩余基质厚度/术前角膜最薄点厚度(postoperative residual corneal stroma thickness /preoperative thinnest corneal thickness，RCST/CT)、术前角膜地形图(前表面高度、后表面高度、后表面diff值)和术前眼压的相关性。

结果：本研究表明手术前后角膜后表面diff差值与屈光度(r=0.419，P=0.014)，AT(r=0.394，P=0.023)，AT/CT(r=0.501，P=0.004)，术前角膜后表面diff值(r=0.501，P=0.004)，RCST(r=-0.385，P=0.033)和RCST/CT(r=-0.401，P=0.025)相关。手术前后角膜后表面高度差值与屈光度(r=0.520，P=0.002)，AT(r=0.504，P=0.003)，AT/CT(r=0.442，P=0.013)，角膜后表面diff值(r=0.624，P=0.000)和RCST/CT(r=-0.394，P=0.028)相关。

结论：AT，RCST，AT/CT，RCST/CT和术前角膜地形图后表面diff值应作为预测术后角膜后表面稳定性的关键性指标，但具体安全限度值有待进一步研究。

METHODS: About 64 patients(64 eyes)were enrolled. The correlation among the changes in posterior corneal surface 6 month after LASIK, surgery method, corneal flap thickness(FT), ablation thickness(AT), postoperative residual corneal stroma thickness(RCST), preoperative thinnest corneal thickness(CT), flap thickness/preoperative thinnest corneal thickness(FT/CT), ablation thickness/preoperative thinnest corneal thickness(AT/CT), postoperative residual corneal stroma thickness/preoperative thinnest corneal thickness(RCST/CT), anterior and posterior preoperative corneal height, the difference of the forward shift in posterior corneal surface(diff value)of preoperative and preoperative intraocular pressure were analyzed.

RESULTS: The changes of diff value between preoperative and postoperative were related with diopter(r=0.419, P=0.014), AT(r=0.394, P=0.023), AT/CT(r=0.501, P=0.004), Diff value of preoperative(r=0.501, P=0.004), RCST(r=-0.385, P=0.033)and RCST/CT(r=-0.401, P=0.025). The changes of height value from posterior corneal surface between preoperative and postoperative were related with diopter(r=0.520, P=0.002), AT(r=0.504, P=0.003), AT/CT(r=0.442, P=0.013), Diff value of preoperative(r=0.624, P=0.000)and RCST/CT(r=-0.394, P=0.028).

CONCLUSION: AT, RCST, AT/CT, RCST/CT and diff value of preoperative should be the key index that predicted the stability of posterior corneal surface after LASIK,the further research will give the range of safety value.