[关键词]
[摘要]
目的：观察曲古抑菌素A(trichostatin A，TSA)作用于兔眼滤过术后滤过泡的形态变化，研究其对术后结膜瘢痕的抑制作用。
方法：兔眼滤过术中结膜下注射TSA、丝裂霉素C(MMC)、PBS，分别于术后3，7，14，21，28d应用Krofeld评分评价滤过泡的形态变化。
结果：TSA组14d内滤过泡弥漫性隆起，28d囊性泡形成。术后14，21d TSA组滤过泡评分高于PBS组，具有统计学差异(P<0.05)。
结论：TSA能够抑制术后结膜瘢痕形成，延长滤过泡存在时间，保持滤过道通畅。
[Key word]
[Abstract]
AIM: To observe the morphologic changes of of filtration blebs after trichostatin A treatment in an experimental glaucoma filtration surgery(GFS).
METHODS: Subconjunctival injection TSA, mitomycin C(MMC)and PBS during the filtering surgery in rabbits. The morphologic changes of filtration blebs were evaluated by Krofeld score method postoperatively days 3, 7, 14, 21, and 28.
RESULTS: TSA induced filteation bleds were elevated diffusely within 14d and cystic blebs formed 28d, filtration bleb score was significantly higher in TSA group than that in PBS group.
CONCLUSION: TSA can keep the aqueous humor outflow by inhibiting scar formation and prolong the existence of the filtration bleb.
[中图分类号]
[基金项目]
陕西省教育厅专项科研计划项目(No.2013JK0785)
