方法：将我院收治的195例重症细菌性角膜炎和结膜炎患者作为观察对象，随机均分为A组、B组和C组，分别给予左氧氟沙星、氧氟沙星和氯霉素进行治疗，统计治疗数据，评价不同治疗方法治疗的效果和耐药性。

结果：采用左氧氟沙星治疗的A组患者痊愈54例(83.1%)，显效7例(10.8%)，有效3例(4.6%)，无效1例(1.5%)； 采用氧氟沙星治疗的B组患者痊愈25例(38.5%)，显效6例(9.2%)，有效23例(35.4%)，无效11例(16.9%)； 采用氯霉素治疗的C组患者痊愈4例(6.2%)，显效3例(4.6%)，有效36例(55.4%)，无效22例(33.8%)，组间治疗效果和耐药性存在显著差异(P<0.05)。

结论：左氧氟沙星治疗重症细菌性结膜炎和角膜炎起效快，效果好，不易产生抗药性，值得推广借鉴。

METHODS: Totally 195 patients with severe bacterial keratitis and conjunctivitis were included in this study. Based on the sequence of enrollment, they were randomly divided into three groups: group A(65 patients)received levofloxacin, group B(65 patients)received suture method under microscope, group C received suture method with loupe besides the same basic operative treatment in the two groups. The curative effect and drug tolerance were observed and compared statistically.

RESULTS: In group A, 54 cases were cured, in the rate of 83.1%, 7 cases(10.8%)were excellent, 3 cases(4.6%)were valid, 1 case(1.5%)was invalid. In group B, 25 cases(38.5%)were cured, 6 cases(9.2%)were excellent, 23 cases(35.4%)were valid, 11 cases(16.9%)were invalid. In group C, 4 cases(6.2%)were cured, 3 cases(4.6%)were excellent, 36 cases(55.4%)were valid, 22 cases(33.8%)were invalid. The curative effect and drug tolerance among groups had obvious differences(P<0.05).

CONCLUSION: Levofloxaoin is effective and safe for the treatment of bacterial conjunctivitis and keratitis, which is not resistant and worthy of promotion.