飞秒激光制瓣LASIK术后不同性别泪膜的变化与分析

Analysis the changes of tear film after LASIK with corneal flap created by femtosecond laser with the different gender

摘要:

目的：观察飞秒激光制瓣LASIK术后不同性别泪膜的变化。

方法：收集2013-08/09于我院行飞秒激光制瓣LASIK术并随访3mo的患者120例240眼，将其按性别分为两组，A组：男55例110眼，B组：女65例130眼，观察两组术前、术后1wk； 1，2，3mo患者的干眼症状评分、泪膜破裂时间(break-up tear time，BUT)、泪液分泌试验(Schirmer Ⅰ test，SⅠt)、角膜荧光素染色(corneal fluorescence stain，FL)评分的变化。

结果：主观干眼症状评分：两组术后1wk； 1，2mo差异有统计学意义(P=0.000，0.023， 0.030)，术后3mo差异无统计学意义(P=0.283)。 BUT：两组术后1wk； 1，2，3mo差异有统计学意义(P=0.000，0.017， 0.026， 0.032)。 SⅠt：两组术后1wk； 1，2mo差异有统计学意义(P=0.012，0.024， 0.018)，术后3mo差异无统计学意义(P=0.206)。 FL评分：两组术后1wk； 1，2，3mo差异有统计学意义(P=0.022，0.015， 0.036， 0.041)。

结论：飞秒激光制瓣LASIK术后泪膜功能的影响男性小于女性。

Abstract:

AIM: To observe the changes of tear film on the patients after laser in situ keratomileusis(LASIK)with corneal flap created by femtosecond laser with the different gender.

METHODS: The 120 myopic patients(240 eyes)who underwent femtosecond laser surgery LASIK from August to September 2013 were collected, and these patients were followed up for 3mo. The patients were divided into two groups according to the gender, group A was male(110 eyes of 55 patients); group B was female(130 eyes of 65 patients). Dry eye symptom score, tear break-up time(BUT), Schirmer Ⅰ test, corneal fluorescein staining were recorded preoperatively and postoperatively in 1wk,1,2,3mo.

RESULTS: Dry eye symptom score: it was statistically significant between two groups after operation in the 1wk,1, 2mo(P=0.000,0.023, 0.030). It had no statistical significance between the two groups in 3mo(P=0.283). BUT: it was statistical significance between two groups after operation in the 1wk,1, 2, 3mo(P=0.000,0.017, 0.026, 0.032). SchirmerⅠ test: it was statistically significant between two groups after operation in the 1wk, 1, 2mo(P=0.012,0.024, 0.018). It had no statistical significance between the two groups in 3mo(P=0.206)Corneal fluorescein staining: it was statistically significant between two groups after operation in the 1wk, 1, 2, 3mo(P=0.022,0.015, 0.036, 0.041).

CONCLUSION: The influence of tear film after femtosecond laser surgery for men less than that for women.