应用3D OCT对青年人黄斑区视网膜神经上皮厚度的研究

Study on macular retinal thickness in young people by using 3D optical coherence tomography

摘要:

目的：以3D 1 000 OCT测量正常青年人黄斑区视网膜厚度，并就测量的可重复性，黄斑厚度与性别的关系等进行研究。同时将检测结果与其他类型OCT检测的数据进行对比，了解不同OCT对黄斑区视网膜厚度检测的一致性。

方法：青年人111例 222眼。用Topcon 3D 1 000 OCT(ver 2.4)的3D扫描模式对受试者双眼黄斑区进行检测。其中12例24眼进行可重复性检查。并将我们测定的结果与其他研究结果进行横向比较。

结果：青年人111例，年龄18～27岁，裸眼或矫正视力全部≥1.0，眼压全部<21mmHg。视网膜平均厚度是273.32±17.08μm，黄斑区视网膜体积为7.73±0.37mm³。黄斑中心凹厚度为161～264(平均200.13±18.81)μm，黄斑中心区厚度在188～273(平均229.00±18.20)μm。男性黄斑中心区厚度大于女性，存在统计学差异。其中12例24眼行重复检查，结果黄斑区各项指标前后两次对比除外环鼻侧外均无统计学差异，黄斑中心区厚度的可重复性好于黄斑中心凹厚度。

结论：黄斑检查的可重复性好，黄斑中心区厚度可重复性好于黄斑中心凹厚度。3D 1000 OCT测量的青年人黄斑中心区厚度是229.00±18.20μm。不同性别黄斑中心区厚度存在差异。

Abstract:

AIM: To measure the macular thickness of normal young people by 3D 1000 optical coherence tomography(OCT)and study the repeatability of measuring results and the relationship between the thicknesses of macular and gender. At the same time, to compare our result with the data of other types of OCT, and to understand the consistency of the measuring results of macular thickness of different types of OCT.

METHODS: Totally 222 eyes in 111 young people were detected using 3D scan mode of Topcon 3D OCT 1 000(ver 2.4). Twelve cases(24 eyes)underwent repeatability check. We took transverse comparison between our measured results with other research's results.

RESULTS:There were 111 cases of young people, whose age were from 18-27 years old, all uncorrected and corrected visual acuity were ≥1.0, all intraocular pressure were <21mmHg. The average thickness of all macular region was 273.32±17.08μm. Retinal volume of macular area was 7.73±0.37mm³. Center thickness was 161-264μm, and the average thickness was 200.13±18.81μm. Central macular thickness were 188-273μm, and the average thickness was 229.00±18.20μm. The central macular thickness in men was significantly greater than that in women, and there was statistical difference. The results of repeated check of 12 cases(24 eyes)in the macular area were no statistical difference except the outer ring of nasal quadrant, and the repeatability of average thickness in central macular thickness was better than in center thickness.

CONCLUSION:The repeatability of macular examination is good. The central macular thickness can be better repeated than the center thickness. The central macular thickness is 229.00±18.20μm in young people, according to the 3D 1000 OCT measurements. There are statistical difference of central macular thickness between different genders.