高危角膜移植排斥反应的预防和治疗进展

Prevention and therapy progress in allograft rejection of high-risk corneal transplantation

摘要:

高危角膜移植术后免疫排斥反应是影响角膜移植成败的首要因素，因此，免疫抑制剂在高危角膜移植排斥反应中的应用占有不可替代的地位。然而，在应用过程中出现许多局部和全身不良反应，为了提高角膜移植成功率，国内外专家、学者在剂型、用药途径以及联合用药方面都做了卓著的研究； 同时在基因工程方面也有可观的进步。本文就高危角膜移植排斥反应的预防和治疗方面做一综述。

Abstract:

High-risk corneal transplantation immunological rejection is a primary factor affecting the success or failure of the corneal transplantation. As a result, application of immunosuppressive agent in high-risk corneal transplantation rejection reaction occupies an irreplaceable position. However, many local and systemic adverse reactions appeared in the process of application. In order to improve the achievement ratio of the corneal transplantation, experts and scholars at home and abroad have obtained remarkable achievements in dosage form, route of administration and drug combination; meanwhile, a considerable progress was also made in genetic engineering. This paper is a review of prevention and treatment on high-risk corneal graft rejection reaction.