PDCD4和B7-H4 在儿童视神经胶质瘤中的表达及临床意义

Expressions and clinical significance of PDCD4 and B7-H4 in optic gliomas in children

摘要:

目的：研究PDCD4和B7-H4 在儿童视神经胶质瘤中的表达及临床意义。

方法：采用免疫组织化学法对52例儿童视神经胶质瘤手术切除标本中PDCD4和B7-H4的表达进行检测，评估PDCD4和B7-H4的表达与儿童视神经胶质瘤临床病理因素的关系。

结果：PDCD4在胶质瘤组织的阳性表达降低：52例胶质瘤组织中PDCD4表达阳性率随着肿瘤恶性程度增加呈降低趋势(P<0.01)； B7-H4在胶质瘤组织的阳性表达增高：B7-H4在52例胶质瘤组织中阳性率随着肿瘤恶性程度增加显著增高(P<0.01)； 脑胶质瘤中PDCD4与B7-H4表达负相关(P<0.01)。

结论：PDCD4和B7-H4与儿童视神经胶质瘤的恶性程度有关，对于儿童视神经胶质瘤的转移防治及预后具有一定的临床意义。

Abstract:

AIM: To study the expressions and clinical significance of PDCD4 and B7-H4 in optic gliomas in children.

METHODS: We used immunohistochemistry to evaluate the expressions of PDCD4 and B7-H4 in specimens from 52 optic gliomas in children cases, and analyzed the correlation of PDCD4 and B7-H4 expression with clinicopathological factors children optic gliomas.

RESULTS: PDCD4 expression reduced in optic glioma tissue: PDCD4 expression rate in 52 cases of optic glioma tissues decreasing was correlated with tumor malignancy increase(P<0.01); B7-H4 positive expression increased in optic glioma tissue: B7-H4 expression rate in 52 cases of optic glioma tissues increasing was correlated with tumor malignancy increase(P<0.01); PDCD4 expression was negatively correlated with B7-H4 expression in optic gliomas(P<0.01).

CONCLUSION: Expressions of PDCD4 and B7-H4 may be clinically relevant to tumor malignancy of optic gliomas in children and prevention of metastasis and prediction of prognosis.