方法：观察持续性角膜上皮缺损患者168 例(包括单疱病毒性角膜炎上皮型58 例； 化学烧伤24例； 胬肉手术术后86例)，随机分成小牛血去蛋白眼用凝胶组(84例)，碱性成纤维细胞生长因子眼用凝胶组(bFGF，84例)。 两组均滴眼4次/d，共7d。观察上皮缺损修复和患眼局部症状、体征等指标。

结果：小牛血去蛋白眼用凝胶组和bFGF组疗效判断指标较治疗前皆有显著性差异(P<0.01)。小牛血去蛋白眼用凝胶组有效率(83.3%)高于bFGF组(69%)； 治疗单疱病毒性角膜炎上皮型角膜炎、化学烧伤和手术所引起的有效率分别为 72.4%，69.2% 和95.2%； 观察过程中未见局部刺激和全身不良反应。

结论：小牛血去蛋白眼用凝胶治疗持续性角膜上皮缺损疗效确切，安全性高。

METHODS: One hundred and sixty-eight cases of corneal epithelial defect(58 cases with herpes simplex keratitis; 24 cases with chemical injury; 85 cases with pterygium operation injury)were randomly divided into two groups: 84 eyes were treated with protein-free calf blood extract eye gel; 84 cases were treated with basic fibroblast growth factor eye gel(bFGF). The bFGF and protein-free calf blood extract eye gels were used 4 times a day. The treatment course was 7d. Epithelial defect restoration, local symptom and sign were observed.

RESULTS: The difference between pre-treatment and post-treatment was significant(P<0.01)in the two groups. The effect of protein-free calf blood extract eye gel(83.3%)group was prior to that of bFGF(69%)for corneal epithelial defect. The effective rate of protein-free calf blood extract eye gel in the herpes simplex keratitis, chemical injury and pterygium operation injury was 72.4%,69.2% and 95.2%. Localized stimulus and adverse reaction of all over the body were not been observed.

CONCLUSION: Protein-free calf blood extract eye gels is valuable and safe for corneal epithelial defect.