方法：选择30例糖尿病视网病变患者和30例健康体检者，检测血清中的果糖胺，并运用采用酶联免疫吸附试验检测血清MMP-9表达水平。

结果：与健康对照组(2.47±1.41pmol/L)比较， 糖尿病视网膜病变患者血清中MMP-9的表达水平(8.14±2.28pmol/L)明显升高(P<0.05)； MMP-9水平与血清中的果糖胺表达水平呈现正相关(r=0.94，P<0.05)。

结论：糖尿病视网膜病变的发生与发展可能与MMP-9表达水平密切相关，MMP-9在糖尿病视网膜病患者血清中的异常表达可能与果糖胺的分泌相关。

METHODS: Serum MMP-9 levels were measured using enzyme-linkedimmunosorbent assays a in 30 health controls and 30 diabetic retinopathy patients, the relationship of MMP-9 and serum fructosamine levels were analyzed。

RESULTS: Compared with healthy controls. The expression levels of MMP-9 indiabetic retinopathy patients were significantly increased \〖(8.14±2.28pmol/L), vs(2.47±1.41pmol/L)\〗, MMP-9 were positive correlation with fructosamine(r=0.94, P<0.05).

CONCLUSION:The occurrence and progress of diabetic retinopathy might be closely related to the expression level of MMP-9, and the abnormal expression of MMP-9 in patients' serum might be associated with the secretion of fructosamine.