方法：前瞻性病例研究。应用3D SIRIUS角膜地形图仪采集并分析LASIK手术后100例200眼患者不同时间点(术前、术后5，30，60min及1d)的角膜前表面4mm光学区的各高阶像差的RMS值，并对检查结果进行方差分析。

结果：LASIK术后5～60min角膜前表面顶点区各高阶像差均明显增大，但均于术后1d恢复至术前水平，差异无统计学意义(P>0.05)； 在各像差中Z₁₇的RMS值增大幅度最大达1126.98%(P<0.01)，Z₁₂增加幅度最小为147.92%(P=0.03)； 各高阶像差增大的峰值不同，根据其特点可分为单峰值期、双峰值和平台型三类； 平均角膜中央厚度在术后30，60min较术后5min时明显增加，并在术后1d明显降低。

结论：LASIK术后角膜前表面顶点区高阶像差会出现明显增大并于1d内恢复至术前水平。

METHODS: A prospective study was designed for 200 eyes of 100 patients who had underwent LASIK. A 3D sirius corneal topography system(SIRIUS)was used to collect and measure the root mean square(RMS)of corneal aberrations at the 4mm optical zones of cornea in different time(preoperation and postoperation of 5, 30, 60min; 1d). Data were analyzed using analysis of variance(ANOVA).

RESULTS: From 5min to 60min after surgery, the higher-order aberrations(HOA)on the peak area of corneal surface were significantly increased, but all in the second day returned to the preoperative level and the difference was not statistically significant(P>0.05). In each aberrations' the root mean square(RMS)of Z₁₇ was markedly increased to maximum 1126.98%(P<0.01), and the minimal increase of Z₁₂ was 147.92%(P=0.03). Their peaks of higher-order aberrations were different. According to their characteristics, they can be divided into single-peak period, double peak, and platform-type. Compared with postoperative 5min, the average central corneal thickness in the postoperative 30 and 60min increased significantly and recovered until the next day.

CONCLUSION: Higher-order aberrations on anterior corneal surface in the early stages after LASIK increase significantly, and return to the preoperative levels within 1d.