方法：以圆锥角膜(keratoconus)为检索词，检索PubMed(1911-01-01/2013-11-10)和CNKI(1960-01-01/2013-11-10)中收录的圆锥角膜文献数量，对文献量进行直线或曲线回归分析以确定文献增长规律及主要影响因素。

结果：国外圆锥角膜逐年累积文献量呈递增趋势，其趋势图呈指数曲线分布(y1=0.8824e^0.7937X，R²=0.9533)。国内圆锥角膜逐年累积文献量呈递增趋势，其趋势图也呈指数曲线分布(y2=0.2441e^1.6073X，R²=0.9957)。PubMed数据库中10种眼科学核心期刊收录文献1 932篇，CNKI数据库中10种眼科学核心期刊收录文献409篇。

结论：国内外圆锥角膜研究的文献量均呈上升趋势，表明圆锥角膜的研究仍是一个热点。影响国外圆锥角膜文献增长的主要因素是学科发展自身固有的规律，影响国内圆锥角膜文献增长的主要因素是学科发展所处的环境。

METHODS:As the index word, quantity of literatures of keratoconus was retrieved in PubMed(from January 1, 1911 to November 10, 2013)and CNKI(from January 1, 1960 to November 10, 2013). The literature linear or curve regression analysis was preceded, and the growth law of the literatures and its main influence factors were determined.

RESULTS: Foreign annual cumulative amount of keratoconus literatures showed an increasing trend with the tendency charts of the exponential(y1=0.8824e^0.7937X, R²=0.9533). Domestic annual cumulative amount of keratoconus literatures also showed an increasing trend with the tendency charts of the exponential(y2=0.2441e^1.6073X, R²=0.9957). Ten PubMed core journals in ophthalmology included 1932 literatures, and 10 CNKI core journals in ophthalmology included 409 literatures.

CONCLUSION: The amount of keratoconus literatures in China and abroad show an upward trend, and keratoconus is still a hot spot of research. A major factor affecting the growth of foreign literature of keratoconus is the inherent discipline of its own development, but the major factor affecting the growth of the domestic literature of keratoconus is the environmental condition in which the subject develops.