[关键词]
[摘要]
目的：比较雷珠单抗和光动力疗法(photodynamic therapy， PDT)治疗湿性年龄相关性黄斑变性(age-related macular degeneration， AMD)的临床疗效。
方法：回顾性分析23例PDT治疗的湿性AMD患者和23例予雷珠单抗玻璃体腔内注射治疗的湿性AMD患者的资料，比较两组在治疗后 1，3，6mo的视力、OCT及FFA变化情况。
结果：两组患者术后1，3mo视力均得到明显提高，两组在统计学意义上无显著差异，雷珠单抗组有2例(9%)患者在治疗后6mo出现视力回降现象，PDT组患者在术后3mo及术后6mo视力变化稳定。
结论：雷珠单抗和PDT治疗湿性AMD，均能有效控制湿性AMD患者病情发展并能改善患者视力，两种疗法疗效的比较在短期内无统计学意义，但是术后6mo，PDT的稳定性优于雷珠单抗。
[Key word]
[Abstract]
AIM: To compare the clinical curative effect with lucentis and photodynamic therapy in the disease of wet age-related macular degeneration.
METHODS: A retrospective study in 23 cases with photodynamic therapy(PDT),and another 23 patients who were injected lucentis. We compared the results of best corrected visual acuity, OCT and FFA after 1mo, 3mo and 6mo.
RESULTS: Both groups had a great significant improvement in best corrected acuity visual at 1mo and 3mo later. The comparison between the two groups had no statistical significance. But the best corrected visual acuity in 2 patients(9%)of lucentis group was lower at 6mo than at 1mo and 3mo.
CONCLUSION: The study showed the two methods for treating wet age-related macular degeneration were effective in short time, but the stability at 6mo of PDT group was better than lucentis group.
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[基金项目]
