[关键词]
[摘要]
目的：观察中高度近视在准分子激光上皮下角膜磨镶术(laser-assisted subepithelial keratomileusis，LASEK)中应用0.1g/L丝裂霉素(mitomycin-C，MMC)抑制术后角膜上皮下雾状混浊(haze)的疗效。
方法：对78例156眼患者行LASEK，随机分成MMC组(86眼)及对照组(70眼)，术中两组分别采用含0.1g/L MMC与平衡盐溶液(BSS)的吸水棉签点蘸激光切削后的基质床。观察患者术后1，3，5，7d； 2wk； 1，3，6mo的症状，裸眼视力，角膜上皮愈合时间及haze形成情况。
结果：术后MMC组haze发生率低于对照组，两组haze形成差异有统计学意义(P<0.05)； 术后角膜上皮愈合时间及裸眼视力均无明显差异。
结论：LASEK术中点蘸法应用0.1g/L MMC可抑制haze的形成。
[Key word]
[Abstract]
AIM: To observe the effects of using 0.1g/L mitomycin-C(MMC)to prevent the formation of haze in laser-assisted subepithelial keratomileusis(LASEK)for moderate and high myopia.
METHODS: Totally 78 cases(156 eyes)were randomly divided into two groups. With group MMC including 86 eyes, 0.1g/L MMC and balanced salt solution(BSS)within sponges dip the ablated zone; The control group(70 eyes)used BBS in the same way. Uncorrected visual acuity(UCVA), corneal epithelial healing time, and the formation of corneal haze 1, 3, 5 and 7d; 2wk; 1,3 and 6mo after surgery were observed.
RESULTS: The incidence of haze of group MMC was lower than the control group, the difference was statistically significant(P<0.05); the corneal epithelial healing time and the postoperative UCVA between the two group had no significant difference(P>0.05).
CONCLUSION: The application of 0.1g/L MMC during LASEK can prevent the formation of haze.
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