方法：将435例482眼翼状胬肉患者随机分为间断缝合组(A组)和连续加锁缝合组(B组)。其中A组239例263眼，B组196例219眼。术后观察随访6～12mo，统计患者手术之后第几天能自然睁开术眼(睁眼时间)，术后并发结膜肉芽肿情况，术后复发情况。

结果：A组平均睁眼时间为4.8±1.8d，B组平均自然睁眼时间为2.6±1.1d，两组相比有统计学差异(t=2.932，P<0.05)。A组中有9眼并发结膜肉芽肿，B组中无1眼并发结膜肉芽肿，两组有统计学差异(χ²=7.637，P<0.05)。A组中有15眼复发，复发率为5.7%，B组中有11眼复发，复发率为5.0%，两组对比无明显差异(χ²=0.108，P>0.05)。

结论：在翼状胬肉切除联合角膜干细胞移植术中，采用连续加锁缝合法，不能降低术后复发率，但能明显降低术后并发结膜肉芽肿的概率，并明显减轻患者术眼刺激症状。

METHODS: A total of 435 patients(482 eyes)with pterygium were randomly divided into two groups: 239 patients(263 eyes)in group A received interrupted suture, while 196 patients(219 eyes)in group B received continuous interlocking suture. During the postoperative follow-up of 6-12 months, the period of time from operation to opening eyes naturally(the time of opening eyes), the conditions of postoperative conjunctival granuloma and the postoperative recurrence rate were calculated.

RESULTS: The average time of opening eyes was 4.8±1.8d in group A and 2.6±1.1d in group B, respectively, demonstrating statistical difference(t=2.932, P<0.05). Nine eyes experienced concurrent appearance of conjunctival granuloma in group A and none appeared in group B, demonstrating statistical difference(χ²=7.637, P<0.05). Recurrence of pterygium occurred in 15 eyes(5.7%)in group A and in 11 eyes(5.0%)in group B, respectively, demonstrating no significant differences(χ²=0.108, P>0.05).

CONCLUSION: Compared to interrupted suture, continuous interlocking suture does not reduce the recurrence rate for the patients receiving excision of pterygium combined with autologous coneal limbus stem cell transplantation. But it can significantly reduce the probability of the concurrent appearance of conjunctival granuloma, and obviously relieve the symptoms of eyes irritation.