[关键词]
[摘要]
目的：观察早期衰老大鼠视网膜色素上皮-光感受器细胞复合体超微结构的变化。
方法：取3月龄及12月龄大鼠视网膜，制成半薄切片，透射电镜下观察视网膜色素上皮-光感受器细胞复合体超微结构的变化。
结果：12月龄大鼠视网膜中出现视网膜色素上皮细胞(retinal pigment epithelium， RPE)凋亡和RPE-光感受器细胞复合体的退行性改变。
结论：视网膜色素上皮-光感受器细胞复合体的退行性改变是视网膜衰老的早期表现。
[Key word]
[Abstract]
AIM:To observe the ultrastructural changes of retinal pigment epithelium(RPE)-photoreceptor complex in early aging rats.
METHODS: Retinas of 3-month old and 12-month old rats were prepared into semi-thin sections and then observed under transmission electron microscope to evaluate the changes of RPE-photoreceptor complex.
RESULTS: Apoptosis of RPE cells and degenerative changes of RPE-photoreceptor complex were found in retinas of 12-month old rats.
CONCLUSION: RPE-photoreceptor complex degeneration is an early manifestation of the retinal aging.
[中图分类号]
[基金项目]
首都医科大学眼科学院重点学科开放课题; 首都卫生发展科研专项项目(No.2011-1001-02); 北京市自然科学基金(No.7132044)
