方法：随机选择准分子激光术后6mo以上、BUT<5s、有眼干、眼酸等症状的干眼患者25例，平均年龄28.60±3.77岁，受试者右眼(试验组)滴用七叶洋地黄双苷滴眼液，左眼(对照组)滴用9g/L生理盐水，于用药前、用药后10，20和30min应用OCT行上下泪河高度和面积的测量。应用单因素方差分析比较各眼用药前后不同时间的差异，配对t检验比较两眼间不同时间的差异。

结果：两组用药后20min下泪河面积(t=2.835，P=0.009)、用药后30min上泪河高度(t=2.368，P=0.026)、面积(t=4.293，P=0.000)和下泪河高度(t=3.060，P=0.005)、面积(t=2.644，P=0.014)试验组均明显大于对照组，其余两组均无统计学上的差异(P>0.05)。两组用药前后各期上下泪河高度和面积均无统计学上的差异(P>0.05)，但试验组用药后有增加的趋势。

结论：七叶洋地黄双苷滴眼液能在一定程度上增加术后干眼患者上下泪河的容量，并保持着较持久的效应。

METHODS: A total of 25 patients, average age being 28.60±3.77, after excimer laser surgery(more than 6 months)were selected in the study. All patients had complications such as dry and sore eye and the tear break-up times(BUT)were less than 5s. The right eyes in the experimental group were given Augentropfen Stulln Mono eye-drop and the left eyes in the control group were given 0.9% normal saline. The heights and cross-sectional areas of the upper and lower tear menisci were measured by OCT before drop instillation and at 10min, 20min and 30min after drop instillation. Differences in each eye at different times were analyzed by one-way variance and compared by sample T test.

RESULTS: The lower tear meniscus cross-sectional area(t=2.835, P=0.009)at 20min after drop instillation, and the upper tear meniscus height(UTMH)(t=2.368, P=0.026), upper tear meniscus cross-sectional area(UTMA)(t=4.293, P=0.000), lower tear meniscus height(LTMH)(t=3.060, P=0.005)and lower tear meniscus cross-sectional area(LTMA)(t=2.644, P=0.014)at 30min after drop instillation in the experimental group were significantly larger than that in the control group with no statistical differences. There were no statistically significant differences in upper and lower tear meniscus heights and cross-sectional areas between two groups before and after taking drugs(P>0.05), however, there was a trend of increase after treatment in the experimental group.

CONCLUSION:Augentropfen Stulln Mono eye-drops can increase the volumes of upper and lower tear meniscus in patients with dry eyes after operation to some degree, and can maintain effects in a relatively long time period.