方法：选取45例90眼2型糖尿病患者和40例80眼非糖尿病患者为研究对象，分析其泪膜破裂时间、基础泪液分泌试验以及角膜荧光素染色指标间的差异，并分析其相关因素。

结果：观察组患者平均泪膜破裂时间为6.23±2.36s，显著短于对照组； 泪液分泌试验滤纸条平均浸润长度为8.65±3.82mm，显著低于对照组； 角膜荧光素染色评分为1.89±1.31分，显著高于对照组； 干眼症发病率达58%，显著高于对照组，差异均具有统计学意义(P<0.05)。Logistic多因素分析显示泪液基础分泌量和泪膜破裂时间为2型糖尿病患者合并干眼症重要的危险因素。

结论：2型糖尿病患者泪膜破裂时间缩短、基础泪液分泌值减少以及角膜荧光素染色评分升高。泪液基础分泌量和泪膜破裂时间为2型糖尿病患者合并干眼症重要的危险因素。

METHODS: Totally 45 patients(90 eyes)with type 2 diabetes and 40 patients(80 eyes)non-diabetic patients were chosen for this study. Tear film break-up time, Schirmer test, and corneal fluorescein staining differences between indicators and its related factors were analyzed.

RESULTS:In diabetes group, the mean tear film break-up time was 6.23±2.36s, significantly shorter than that of the control group; Schirmer infiltration experiments average length of filter strips was 8.65±3.82mm, significantly lower than that of the control group; corneal fluorescein staining score was 1.89±1.31points, significantly higher. The incidence rate of dry eye was 58%, was significantly higher, the difference had statistically significant(P<0.05). The results of Logistic Multivariate analysis showed that basal secretion of tear volume and tear film break-up time were risk factors for type 2 diabetic patients with dry eye.

CONCLUSION: In type 2 diabetes patients, the tear film breakup time is shortened, and the basal tear secretion is decreased corneal fluorescein staining score increased.Basal secretion of tear volume and tear film break-up time was risk factors for type 2 diabetic patients with dry eye.