前节OCT和pentacam及A超在测量角膜厚度上的比较

Comparison of central corneal thickness measured by anterior segment optical coherence tomography, pentacam and ultrasonic pachymetry

摘要:

目的：对比分析前节OCT、pentacam三维眼前节分析仪及A超在测量角膜厚度上的差异性。

方法：回顾研究2013-01/05在我院行准分子激光近视矫正手术的患者43例86眼。利用前节OCT、pentacam以及A超测量患者的角膜厚度，对三组数据对比分析，利用配对t检验以及相关分析进行统计学分析。

结果：前节OCT、pentacam及A超测量患者的中央角膜厚度分别为535±52，550±52，550±51μm。配对t检验提示前节OCT和pentacam及A超测量结果均具有统计学差异(P<0.01)，而pentacam和A超测量结果配对t检验提示无统计学差异(P=0.82)。三种测量结果均具有显著相关性，其相关性依次为：pentacam和A超为0.998，前节OCT和A超为0.993，而前节OCT和pentacam为0.991(P<0.01)。

结论：前节OCT测量角膜中央厚度结果偏薄，而pentacam测量结果和作为金标准的A超结果相近。

Abstract:

AIM: To investigate and analyze the differences in central corneal thickness(CCT)measurement by anterior segment optical coherence tomography(AS-OCT), pentacam rotating Scheimpflug camera and ultrasonic pachymetry(USP).

METHODS: The retrospective study measured CCT of 43 patients(86 eyes)performed excimer laser myopia corrective surgery by the same examiner using RTVue AS-OCT with an anterior segment adaptor, pentacam rotating Scheimpflug camera, and PACSCAN300P USP. Data of three groups were compared and statistically analyzed by pair t test.

RESULTS: The mean CCT(±SD)measured by AS-OCT,pentacam and USP were 535±52, 550±52, 550±51μm, respectively. Paired-sample t test showed that the results of AS-OCT, pentacam and USP were statistically different. There were no statistically significant differences in the mean CCT between the pentacam and USP group. Significant correlations of measurement result were found between pentacam and USP(r=0.998, P<0.01), FD-OCT and USP(r=0.993, P<0.01), and AS-OCT and pentacam(r=0.991, P<0.01).

CONCLUSION:RTVue AS-OCT significantly under estimates the CCT, while the measurement results by pentacam are similar to those by USP which is regarded as the golden standard.