方法：根据RB最新国际分期，对11例11眼A～D期RB患者，通过股动脉插管至眼动脉，使用马法兰(melphalan)经眼动脉灌注，对RB患者实施动脉化疗。

结果：所选患者共实施眼动脉灌注化疗23次，随访3～12mo，其中8例肿瘤明显缩小、钙化，2例病情进展，实施眼球摘除，1例失访。除部分患者术后短暂的恶心、呕吐、发热，没有出现死亡、中风、骨髓抑制等严重并发症。

结论：所选患者中，A、B、C期9例，7例有效，1例继续进展，1例失访，有效率88%； 2例D期患者1例有效，1例继续进展，有效率50%。

METHODS: Eleven cases(11 eyes)of RB, ranging from stage A to D according to the latest International Intraocular Retinoblastoma classification, were treated with melphalan infusion by the ophthalmic artery.

RESULTS: Such intra-arterial chemotherapy was administered for 23 times and the patients were followed up for 3-12 months. During the follow-up, 8 cases were effective with significant tumor shrinking and calcification; 2 patients progressed and received enucleation of eyeballs; 1 case was lost to follow-up. Postoperative transient nausea, vomiting and fever appeared in some cases, but serious complications were not found, such as death, stroke, myelosuppression,etc.

CONCLUSION: Among 9 cases from group A, B and C, 7 cases were effective, 1 case continued to progress and 1 case was lost to follow-up, and the effective rate was 88%. In the 2 cases of group D, 1 case was effective and the other continueed to progress, so the effective rate was 50%.