糜蛋白酶治疗Ⅲ级前房积血42例的临床分析

Clinical analysis on the chymotrypsin treatment of 42 patients with contusive hyphema at grade III

摘要:

目的：探讨糜蛋白酶治疗Ⅲ级挫伤性前房积血的疗效。

方法：回顾性分析Ⅲ级挫伤性前房积血84例84眼，随机分成治疗组42例和对照组42例：治疗组行常规治疗并加用糜蛋白酶处理； 对照组行常规保守治疗。观察两组前房积血吸收，治疗后视力恢复及前房积血后并发症发生的情况。

结果：两组患者经治疗后前房积血均吸收，大多数患者视力有不同程度提高； 两组间视力恢复情况比较差异无统计学意义(P>0.05)； 治疗组前房积血吸收时间7.45±0.35d较对照组10.24±0.56d明显缩短(P<0.01)； 治疗组前房积血吸收后并发症发生率较低。

结论：糜蛋白酶治疗Ⅲ级挫伤性前房积血，积血吸收快，不良反应及并发症少。

Abstract:

AIM: To explore the curative effect of chymotrypsin in treating contusive hyphema at grade Ⅲ.

METHODS: Totally 84 patients(84 eyes)with contusive hyphema at grade Ⅲ were analyzed retrospectively. They were randomly divided into treatment group(42 cases)and control group(42 cases). The chymotrypsin was administrated in addition to routine treatment for treatment group, while the control group adoptedroutine treatment. Observation was made regarding the hyphema absorption time, visual recovery and complications.

RESULTS: The hyphema were absorbed after treatment in both groups, and visual acuity were improved at different levels in most patients. There were no significant differences in visual acuity after treatment in both two groups(P>0.05). The hyphema absorption time of the treatment group(7.45±0.35)d was significantly shorter than that of the control group(10.24±0.56)d. There was significant difference in the absorption time between the two groups(P<0.01). The complications occurrence was muchlower in the treatment group than that in the control group.

CONCLUSION: The hematocele of contusive hyphema patients at grade Ⅲ can be absorbed quickly through the chymotrypsin treatment, with less adverse reactions and complications.