氧化应激诱导视网膜神经节细胞凋亡的研究进展

Research advances of oxidative stress-induced apoptosis of retinal ganglion cells

摘要:

视网膜神经节细胞(retinal ganglion cells，RGCs)凋亡是青光眼、糖尿病视网膜病变、视神经炎等多种疾病过程中的一个重要环节。在这些疾病过程中，氧化应激参与诱导RGCs的凋亡。近年的实验研究发现抗氧化应激药物对RGCs有良好的保护作用。我们将近年来氧化应激诱导RGCs凋亡以及相关抗氧化应激药物的研究进展做一综述。

Abstract:

Apoptosis of retinal ganglion cells(RGCs)is an important step in the mechanism of a variety of diseases such as glaucoma, diabetic retinopathy, optic neuritis etc. In these diseases, oxidative stress induces the aopoptosis of RGCs. In recent years, many experimental studies have found that anti-oxidative stress drugs have a powerful protective efficacy in RGCs. This article reviewed the recent advances in the researches on oxidative stress-induced apoptosis of RGCs and related anti-oxidative stress drugs.