方法：选择聚乳酸为原材料，经过加热塑形裁切得到泪道塞； 采取摘除主泪腺、摘除第三眼睑、摘除Harder氏腺，得到兔干眼动物模型； 观察植入泪道塞前后，泪液分泌试验、热原实验； 观察泪道塞组织相容性及降解时间。

结果：泪道塞植入后，能明显改善兔干眼模型泪液分泌试验观察指标，无热原反应，组织相容性佳，完全降解时间约为2mo。

结论：广泛用于生物医学领域的聚乳酸材料制备的可降解泪道塞对兔无毒害作用，具有极好的安全性及生物相容性，成本低，具有进一步研究价值及临床应用前景。

METHODS:To produce punctal plugs with polylactic acid. To model the dry eye rabbits by removing of the main lacrimal gland, the third eyelid and Harder's gland; To record the results of Schirmer test and the pyrogen test before and after the implantation of punctal plugs; Schirmer test and pyrogen test were performed before and after punctal plug implantation. The lacrimal plugs histocompatibility and the degradation time were also observed.

RESULTS: It can significantly improve the Schirmer test of dry eye rabbits to implant punctual plugs. No pyrogenic reactions had been discovered. Good histocompatibility was achieved and the plugs would degrade within 2 months.

CONCLUSION:The plugs produced by polylactic acid biodegradable material, which is widely used in biomedical fields, have no toxic effects on rabbits. It's safe and inexpensive, so it's valuable for further research and clinical application.