方法：前瞻性、对照性临床病例研究。比较结膜乳头磨削术(8例12眼)与结膜乳头切除术(9 例12眼)两种方法治疗巨大结膜乳头，手术前后的眼痒、流泪、畏光、异物感等症状和结膜乳头、角膜上皮等体征的变化情况。

结果：两组病例术后1，2，4wk不适症状、体征明显改善，与术前相比统计学差异有显著性意义(P<0.01)。但术后1，2，4wk巨大结膜乳头体征、术后2wk角膜损伤修复情况等评分，磨削治疗组治疗效果优于手术切除组(P<0.05)。

结论：结膜乳头磨削术能使粗糙的结膜创面快速变平，减轻不适症状，促进角结膜上皮修复，是治疗重度春季角结膜炎巨大结膜乳头的简单、安全、有效的治疗方式。

METHODS: The prospective and controlled study was performed in 17 patients(24 eyes)with VKC. Eight patients(12 eyes)with giant conjunctival papillae were treated with grinding technique and 9 patients(12 eyes)were performed with conjunctival papillectomy, respectively. A comparison was made on the changes of symptoms including itching, tearing, light sensitivity and grittiness and physical signs of conjunctival papilla and the corneal epithelium before and after surgery.

RESULTS:The symptoms and signs in the first week, the second week and the forth week after the operation were obviously improved in the two groups, and differences in these aspects before and after surgery were of statistical significance(P<0.01). However, by grading of the signs of huge conjunctival nipple in the first week, the second week and the forth week after the operation, and conditions of repair of corneal damage in the second postoperative week, the result showed that efficacy of the grinding group was better than that of the surgical removal group(P<0.05).

CONCLUSION:Conjunctival nipples grinding operation can make the rough conjunctival wound flat quickly, relieve symptoms, and promote the repair of keratoconjunctival epithelium. And it is an effective, safe, and simple method to treat the severe VKC with huge conjunctival nipples.